Literature summary for 2.5.1.58 extracted from

Mijimolle, N.; Velasco, J.; Dubus, P.; Guerra, C.; Weinbaum, C.A.; Casey, P.J.; Campuzano, V.; Barbacid, M.
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development (2005), Cancer Cell, 7, 313-324.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
farnesyl diphosphate + protein-cysteine	Mus musculus	protein farnesylation is essential for early embryonic proliferation but dispensable for postnatal development and adult homeostasis. Ablation of FTase during tumor progression results in significant tumor reduction	S-farnesyl protein + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	protein farnesylation is essential for early embryonic proliferation	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
farnesyl diphosphate + protein-cysteine	protein farnesylation is essential for early embryonic proliferation but dispensable for postnatal development and adult homeostasis. Ablation of FTase during tumor progression results in significant tumor reduction	Mus musculus	S-farnesyl protein + diphosphate	-	?

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Release 2023.1 (January 2023)