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Literature summary for 2.5.1.57 extracted from

  • Van Rinsum, J.; van Dijk, W.; Hooghwinkel, G.J.M.; Ferwerda, W.
    Subcellular localization and tissue distribution of sialic acid-forming enzymes. N-acetylneuraminate-9-phosphate synthase and N-acetylneuraminate 9-phosphatase (1984), Biochem. J., 223, 323-328.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
NaF
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.21
-
N-acetyl-D-mannosamine 6-phosphate in presence of NaF Rattus norvegicus
0.25
-
N-acetyl-D-mannosamine 6-phosphate
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O Rattus norvegicus final steps of the biosynthetic pathway of N-acetylneuraminic acid N-acetyl-neuraminate 9-phosphate + phosphate
-
?
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O Rattus norvegicus Wistar final steps of the biosynthetic pathway of N-acetylneuraminic acid N-acetyl-neuraminate 9-phosphate + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
rat
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Rattus norvegicus
-
erythrocyte
-
Rattus norvegicus
-
intestinal mucosa
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
muscle
-
Rattus norvegicus
-
pancreas
-
Rattus norvegicus
-
salivary gland
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
thymus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O
-
Rattus norvegicus N-acetyl-neuraminate 9-phosphate + phosphate
-
?
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O final steps of the biosynthetic pathway of N-acetylneuraminic acid Rattus norvegicus N-acetyl-neuraminate 9-phosphate + phosphate
-
?
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O
-
Rattus norvegicus Wistar N-acetyl-neuraminate 9-phosphate + phosphate
-
?
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O final steps of the biosynthetic pathway of N-acetylneuraminic acid Rattus norvegicus Wistar N-acetyl-neuraminate 9-phosphate + phosphate
-
?