Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + D-arabinose 5-phosphate + H2O | Escherichia coli | - |
3-deoxy-D-manno-octulosonate 8-phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | development of a one-pot enzyme essay for 3-deoxy-D-manno-octulosonate 8-phosphate synthesis, the reaction process involves the isomerization of D-ribulose 5-phosphate to D-arabinose 5-phosphate catalyzed by D-arabinose 5-phosphate isomerase (KdsD), the aldol condensation of D-arabinose 5-phosphate and phosphoenolpyruvate (PEP) catalyzed by KDO 8-phosphate synthetase (KdsA), and the hydrolysis of KDO-8-phosphate catalyzed by KDO 8-phosphate phosphatase (KdsC), the poduct is transferred to lipid A by KDO transferase from Escherichia coli (WaaA), method, overview | Escherichia coli | ? | - |
? | |
phosphoenolpyruvate + D-arabinose 5-phosphate + H2O | - |
Escherichia coli | 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
KDO 8-phosphate synthetase | - |
Escherichia coli |
KdsA | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme synthesizes 3-deoxy-D-manno-octulosonic acid, that is an important component of the nonrepeating core oligosaccharide part of bacterial lipopolysaccharides and in capsular polysaccharides of many bacteria | Escherichia coli |