Literature summary for 2.5.1.54 extracted from

Walker, S.R.; Parker, E.J.
Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-D-arabino heptulosonate 7-phosphate synthase (2006), Bioorg. Med. Chem. Lett., 16, 2951-2954.

Search for more literature for 2.5.1.54

Inhibitors

Inhibitors	Comment	Organism	Structure
tetraammonium (((carboxymethyl)[(2S,3R,4S)-2,3,4-trihydroxy-5-(phosphonatooxy)pentyl]amino)methyl)phosphonate	IC50: 0.0066 mM	Escherichia coli

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	required	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O	-	Escherichia coli	2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
3-deoxy-D-arabino heptulosonate 7-phosphate synthase	-	Escherichia coli
DAH7P synthase	-	Escherichia coli

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0066	-	IC50: 0.0066 mM	Escherichia coli	tetraammonium (((carboxymethyl)[(2S,3R,4S)-2,3,4-trihydroxy-5-(phosphonatooxy)pentyl]amino)methyl)phosphonate

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Release 2023.1 (January 2023)