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Literature summary for 2.5.1.49 extracted from
- O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast. Further purification and characterization as a pyridoxal enzyme (1976), J. Biochem., 80, 777-785.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal | inhibits the activity competitively with respect to pyridoxal 5'-phosphate | Saccharomyces cerevisiae |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| O-acetyl-L-homoserine + H2S | Saccharomyces cerevisiae | - |
L-homocysteine + acetic acid | - |
? | |
Organic Solvent Stability
| Organic Solvent | Comment | Organism |
|---|---|---|
| urea | denatured by 2.0 M urea | Saccharomyces cerevisiae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
baker's yeast | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 25.2 | - |
- |
Saccharomyces cerevisiae |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, can be stored without any loss of activity | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| O-acetyl-L-homoserine + H2S | - |
Saccharomyces cerevisiae | L-homocysteine + acetic acid | - |
? | |
| O-acetyl-L-homoserine + methyl mercaptan | - |
Saccharomyces cerevisiae | L-methionine + acetic acid | - |
? | |
| O-acetyl-L-serine + H2S | - |
Saccharomyces cerevisiae | L-cysteine + acetic acid | - |
? | |
| O-acetyl-L-serine + methanethiol | reaction only in phosphate buffer, relative activity compared to O-acetyl-L-homoserine 14.8% | Saccharomyces cerevisiae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| OAH | - |
Saccharomyces cerevisiae |
| OAS-OAH sulfhydrylase | - |
Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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