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Literature summary for 2.5.1.48 extracted from

  • Aitken, S.M.; Kim, D.H.; Kirsch, J.F.
    Escherichia coli cystathionine gamma-synthase does not obey ping-pong kinetics. Novel continuous assays for the elimination and substitution reactions (2003), Biochemistry, 42, 11297-11306.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloned from strain JM103, expression in strain DH10B Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information detailed kinetics of elimination and replacement reaction, overview Escherichia coli
0.1
-
L-cysteine pH 7.8, 25°C, replacement reaction, ordered mechanism Escherichia coli
0.11
-
L-cysteine pH 7.8, 25°C, replacement reaction, modified ping-pong mechanism Escherichia coli
1.2
-
O-succinyl-L-homoserine pH 7.8, 25°C, replacement reaction, ordered mechanism Escherichia coli
1.3
-
O-succinyl-L-homoserine pH 7.8, 25°C, elimination reaction, modified ping-pong mechanism Escherichia coli
2.5
-
O-succinyl-L-homoserine pH 7.8, 25°C, replacement reaction, modified ping-pong mechanism Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
O-succinyl-L-homoserine + L-cysteine Escherichia coli first step in bacterial transsulfuration pathway L-cystathionine + succinate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
O4-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate enzyme performs an elimination or a replacement reaction, reaction mechanism, formation of an aldimine intermediate, overview Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme performs an elimination or a replacement reaction Escherichia coli ?
-
?
O-succinyl-L-homoserine elimination reaction Escherichia coli succinate + pyruvate + NH3
-
?
O-succinyl-L-homoserine + L-cysteine first step in bacterial transsulfuration pathway Escherichia coli L-cystathionine + succinate
-
?
O-succinyl-L-homoserine + L-cysteine replacement reaction Escherichia coli L-cystathionine + succinate
-
?

Synonyms

Synonyms Comment Organism
CGS
-
Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8
-
O-succinyl-L-homoserine pH 7.8, 25°C, elimination reaction, modified ping-pong mechanism Escherichia coli
117
-
L-cysteine pH 7.8, 25°C, replacement reaction, ordered mechanism Escherichia coli
117
-
O-succinyl-L-homoserine pH 7.8, 25°C, replacement reaction, ordered mechanism Escherichia coli
121
-
L-cysteine pH 7.8, 25°C, replacement reaction, modified ping-pong mechanism Escherichia coli
121
-
O-succinyl-L-homoserine pH 7.8, 25°C, replacement reaction, modified ping-pong mechanism Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
elimination reaction Escherichia coli
7.8
-
replacement reaction Escherichia coli

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent on Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Escherichia coli