Literature summary for 2.5.1.46 extracted from

Cano, V.S.; Jeon, G.A.; Johansson, H.E.; Henderson, C.A.; Park, J.H.; Valentini, S.R.; Hershey, J.W.; Park, M.H.
Mutational analyses of human eIF5A-1--identification of amino acid residues critical for eIF5A activity and hypusine modification (2008), FEBS J., 275, 44-58.

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Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	mutants of substrate [eIF5A-1-precursor]-lysine with changes in residue K50, and mutants G52A and K55A are no substrates. The hypusine site loop has critical importance in eIF5A function and hypusine modification	Saccharomyces cerevisiae	?	-	?
[eIF5A-1-precursor]-lysine + spermidine	-	Saccharomyces cerevisiae	[eIF5A-1-precursor]-deoxyhypusine + propane-1,3-diamine	-	?

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Release 2023.1 (January 2023)