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Literature summary for 2.5.1.46 extracted from

  • Lee, Y.; Kim, H.K.; Park, H.E.
    Park, M.H.; Joe, Y.A.: Effect of N1-guanyl-1,7-diaminoheptane, an inhibitor of deoxyhypusine synthase, on endothelial cell growth, differentiation and apoptosis (2002), Mol. Cell. Biochem., 237, 69-76.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N1-guanyl-1,7-diaminoheptane
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[eIF5A-precursor]-lysine + spermidine Homo sapiens posttranslational activation of eIF-5A which has a specialized role in proliferation and in serum starvation-induced apoptosis in endothelial cells [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
umbilical vein endothelium
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[eIF5A-precursor]-lysine + spermidine
-
Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine ?
[eIF5A-precursor]-lysine + spermidine posttranslational activation of eIF-5A which has a specialized role in proliferation and in serum starvation-induced apoptosis in endothelial cells Homo sapiens [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
?