Cloned (Comment) | Organism |
---|---|
gene AtNAS4, overexpression of AtNAS4 both in the Salk 135507 mutant and the wild-type genetic backgrounds | Arabidopsis thaliana |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of a mutant Salk 135507 carrying a T-DNA insertion in gene AtNAS4 | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine | Arabidopsis thaliana | - |
3 S-methyl-5'-thioadenosine + nicotianamine | - |
? | |
3 S-adenosyl-L-methionine | Arabidopsis thaliana Col-0 | - |
3 S-methyl-5'-thioadenosine + nicotianamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q6L5P3 | gene AtNAS4 | - |
Arabidopsis thaliana Col-0 | Q6L5P3 | gene AtNAS4 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
root | - |
Arabidopsis thaliana | - |
shoot | - |
Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 S-adenosyl-L-methionine | - |
Arabidopsis thaliana | 3 S-methyl-5'-thioadenosine + nicotianamine | - |
? | |
3 S-adenosyl-L-methionine | - |
Arabidopsis thaliana Col-0 | 3 S-methyl-5'-thioadenosine + nicotianamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AtNAS4 | - |
Arabidopsis thaliana |
nicotianamine synthase 4 | - |
Arabidopsis thaliana |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Arabidopsis thaliana |
General Information | Comment | Organism |
---|---|---|
evolution | AtNAS4 is the fourth member of the Arabidopsis thaliana NAS gene family | Arabidopsis thaliana |
malfunction | a mutant Salk 135507 carrying a T-DNA insertion in AtNAS4, as well as lines overexpressing AtNAS4 both in the mutant and the wild-type genetic backgrounds, are used to decipher the role of AtNAS4 in nicotinamine synthesis, iron homeostasis and the plant response to iron deficiency or cadmium supply, severe chlorotic phenotype in insertion mutant plants, young leaves displayed interveinal chlorosis, overexpression of AtNAS4 leads to enhanced nicotianamine accumulation. In the shoots, whereas the manganese concentration is unchanged, differences in zinc and copper are observed in iron sufficient-conditions but not in iron-deficient conditions | Arabidopsis thaliana |
physiological function | Arabidopsis thaliana isozyme nicotianamine synthase 4 is required for proper response to iron deficiency and to cadmium exposure. Role of AtNAS4 in nicotinamine synthesis, iron homeostasis and the plant response to iron deficiency or cadmium supply | Arabidopsis thaliana |