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Literature summary for 2.5.1.43 extracted from

  • Koen, E.; Besson-Bard, A.; Duc, C.; Astier, J.; Gravot, A.; Richaud, P.; Lamotte, O.; Boucherez, J.; Gaymard, F.; Wendehenne, D.
    Arabidopsis thaliana nicotianamine synthase 4 is required for proper response to iron deficiency and to cadmium exposure (2013), Plant Sci., 209, 1-11.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene AtNAS4, overexpression of AtNAS4 both in the Salk 135507 mutant and the wild-type genetic backgrounds Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information generation of a mutant Salk 135507 carrying a T-DNA insertion in gene AtNAS4 Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine Arabidopsis thaliana
-
3 S-methyl-5'-thioadenosine + nicotianamine
-
?
3 S-adenosyl-L-methionine Arabidopsis thaliana Col-0
-
3 S-methyl-5'-thioadenosine + nicotianamine
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q6L5P3 gene AtNAS4
-
Arabidopsis thaliana Col-0 Q6L5P3 gene AtNAS4
-

Source Tissue

Source Tissue Comment Organism Textmining
root
-
Arabidopsis thaliana
-
shoot
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine
-
Arabidopsis thaliana 3 S-methyl-5'-thioadenosine + nicotianamine
-
?
3 S-adenosyl-L-methionine
-
Arabidopsis thaliana Col-0 3 S-methyl-5'-thioadenosine + nicotianamine
-
?

Synonyms

Synonyms Comment Organism
AtNAS4
-
Arabidopsis thaliana
nicotianamine synthase 4
-
Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Arabidopsis thaliana

General Information

General Information Comment Organism
evolution AtNAS4 is the fourth member of the Arabidopsis thaliana NAS gene family Arabidopsis thaliana
malfunction a mutant Salk 135507 carrying a T-DNA insertion in AtNAS4, as well as lines overexpressing AtNAS4 both in the mutant and the wild-type genetic backgrounds, are used to decipher the role of AtNAS4 in nicotinamine synthesis, iron homeostasis and the plant response to iron deficiency or cadmium supply, severe chlorotic phenotype in insertion mutant plants, young leaves displayed interveinal chlorosis, overexpression of AtNAS4 leads to enhanced nicotianamine accumulation. In the shoots, whereas the manganese concentration is unchanged, differences in zinc and copper are observed in iron sufficient-conditions but not in iron-deficient conditions Arabidopsis thaliana
physiological function Arabidopsis thaliana isozyme nicotianamine synthase 4 is required for proper response to iron deficiency and to cadmium exposure. Role of AtNAS4 in nicotinamine synthesis, iron homeostasis and the plant response to iron deficiency or cadmium supply Arabidopsis thaliana