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Literature summary for 2.5.1.39 extracted from
- Characterization of polyprenyldiphosphate: 4-hydroxybenzoate polyprenyltransferase from Escherichia coli (1994), Biochim. Biophys. Acta, 1212, 93-102.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| CHAPS | 46% increase at 0.01% | Escherichia coli |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NaCl | increasing concentrations in the presence of 5 mM Mg2+ result in inhibition | Escherichia coli | |
| sodium deoxycholate | - |
Escherichia coli | |
| Triton X-100 | - |
Escherichia coli | |
| Tween 80 | - |
Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.022 | - |
farnesyl diphosphate | pH 7.8, 37°C | Escherichia coli | |
| 0.031 | - |
solanesyl diphosphate | pH 7.8, 37°C | Escherichia coli | |
| 0.254 | - |
geranylgeranyl diphosphate | pH 7.8, 37°C | Escherichia coli | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Escherichia coli | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | can replace Mg2+ to some extent | Escherichia coli | |
| Mg2+ | optimum between 20 and 100 mM | Escherichia coli | |
| Mn2+ | can replace Mg2+ to some extent | Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| solanesyl diphosphate + 4-hydroxybenzoate | Escherichia coli | involved in the biosynthesis of ubiquinone | diphosphate + 3-solanesyl-4-hydroxybenzoate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0006 | - |
in the presence of 5 mM Co2+ | Escherichia coli |
| 0.0013 | - |
in the presence of 5 mM Mn2+ | Escherichia coli |
| 0.014 | - |
in the presence of 5 mM Mg2+ | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| farnesyl diphosphate + 4-hydroxybenzoate | - |
Escherichia coli | farnesyl-4-hydroxybenzoate + diphosphate | - |
? | |
| geranyl diphosphate + 4-hydroxybenzoate | - |
Escherichia coli | 3-geranyl-4-hydroxybenzoate + diphosphate | - |
? | |
| geranylgeranyl diphosphate + 4-hydroxybenzoate | - |
Escherichia coli | geranylgeranyl-4-hydroxybenzoate + diphosphate | - |
? | |
| solanesyl diphosphate + 4-hydroxybenzoate | - |
Escherichia coli | diphosphate + 3-solanesyl-4-hydroxybenzoate | - |
? | |
| solanesyl diphosphate + 4-hydroxybenzoate | involved in the biosynthesis of ubiquinone | Escherichia coli | diphosphate + 3-solanesyl-4-hydroxybenzoate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
- |
Escherichia coli |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.7 | 9.4 | 50% activity at pH 6.7 and pH 9.4 | Escherichia coli |
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