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Literature summary for 2.5.1.39 extracted from
- Nonaprenyl-4-hydroxybenzoate transferase, an enzyme involved in ubiquinone biosynthesis, in the endoplasmic reticulum-Golgi system of rat liver (1990), J. Biol. Chem., 265, 1158-1164.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| beta-octyl glucoside | - |
Rattus norvegicus |  |
| deoxycholate | complete inhibition at 0.5% | Rattus norvegicus | |
| additional information | no inhibitor: taurodeoxycholate | Rattus norvegicus | |
| sodium deoxycholate | - |
Rattus norvegicus | |
| Triton X-100 | complete inhibition at 0.5% | Rattus norvegicus | |
| Tween 80 | - |
Rattus norvegicus | |
| Zn2+ | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasmic membrane | - |
Rattus norvegicus | - |
- |
| Golgi vesicle | Golgi III vesicles, high specific activity, associated with inner luminal surface of microsomal vesicles | Rattus norvegicus | - |
- |
| lysosome | - |
Rattus norvegicus | 5764 | - |
| microsome | smooth II microsome, high specific activity, associated with inner luminal surface of microsomal vesicles | Rattus norvegicus | - |
- |
| mitochondrion | low activity | Rattus norvegicus | 5739 | - |
| additional information | at low levels: rough and smooth I microsomes, mitochondria, not: peroxisomes, cytosol | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| solanesyl diphosphate + 4-hydroxybenzoate | Rattus norvegicus | involved in the biosynthesis of ubiquinone | diphosphate + 3-solanesyl-4-hydroxybenzoate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | no substrate: nonaprenyl monophosphate | Rattus norvegicus | ? | - |
? | |
| solanesyl diphosphate + 4-hydroxybenzoate | i.e. nonaprenyl diphosphate | Rattus norvegicus | diphosphate + 3-solanesyl-4-hydroxybenzoate | - |
? | |
| solanesyl diphosphate + 4-hydroxybenzoate | involved in the biosynthesis of ubiquinone | Rattus norvegicus | diphosphate + 3-solanesyl-4-hydroxybenzoate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
microsomes | Rattus norvegicus |
| 8 | 9 | mitochondria | Rattus norvegicus |
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Release 2023.1 (January 2023)
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