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Literature summary for 2.5.1.31 extracted from

  • Teng, K.H.; Chen, A.P.; Kuo, C.J.; Li, Y.C.; Liu, H.G.; Chen, C.T.; Liang, P.H.
    Fluorescent substrate analog for monitoring chain elongation by undecaprenyl pyrophosphate synthase in real time (2011), Anal. Biochem., 417, 136-141.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
D26A site-directed mutagenesis Escherichia coli
S83A site-directed mutagenesis Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
farnesyl thiodiphosphate
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information fluorescence-based UPPS kinetic measurements, kinetics of the single-turnover reaction of (2E,6E)-8-O-(N-methyl-2-aminobenzoyl)-3,7-dimethyl-2,6-octandien-1-diphosphate chain elongation catalyzed by UPPS, overview Escherichia coli
0.0004
-
(2E,6E)-farnesyl diphosphate pH 7.5, 25°C Escherichia coli
0.0011 0.0015 (2E,6E)-8-(N-methyl-2-aminobenzoyloxy)-3,7-dimethyl-2,6-octandien-1-diphosphate pH 7.5, 25°C Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate Escherichia coli
-
8 diphosphate + ditrans,octacis-undecaprenyl diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-8-(N-methyl-2-aminobenzoyloxy)-3,7-dimethyl-2,6-octandien-1-diphosphate + 8 isopentenyl diphosphate a fluorescent analog of farnesyl diphosphate Escherichia coli ?
-
?
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate
-
Escherichia coli 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate
-
?

Synonyms

Synonyms Comment Organism
undecaprenyl pyrophosphate synthase
-
Escherichia coli
UPPs
-
Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5
-
(2E,6E)-farnesyl diphosphate pH 7.5, 25°C Escherichia coli
11.2
-
(2E,6E)-8-(N-methyl-2-aminobenzoyloxy)-3,7-dimethyl-2,6-octandien-1-diphosphate pH 7.5, 25°C Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0013
-
pH 7.5, 25°C, versus (2E,6E)-farnesyl diphosphate Escherichia coli farnesyl thiodiphosphate
0.0024 0.0039 pH 7.5, 25°C, versus (2E,6E)-8-O-(N-methyl-2-aminobenzoyl)-3,7-dimethyl-2,6-octandien-1-diphosphate Escherichia coli farnesyl thiodiphosphate

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.0041
-
isopentenyl diphosphate pH 7.5, 25°C, with (2E,6E)-farnesyl diphosphate Escherichia coli
0.0232 0.0279 isopentenyl diphosphate pH 7.5, 25°C, with (2E,6E)-8-O-(N-methyl-2-aminobenzoyl)-3,7-dimethyl-2,6-octandien-1-diphosphate Escherichia coli