Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E,6E,10E)-4-methylfarnesyl diphosphate | competitive inhibitor against (2Z,6E,10E)-geranylgeranyl diphosphate | Bacillus subtilis | |
(2Z,6E,10E)-4-methyl-geranylgeranyl diphosphate | allylic substrate homologue, competitive inhibitor against the allylic primer. It also acts as a strong noncompetitive inhibitor against isopentenyl diphosphate | Bacillus subtilis | |
(E)-3-methyl-3-pentenyl diphosphate | reactive as substrate and competitive inhibition profile | Bacillus subtilis | |
additional information | Z-isomer ZHIPP, (Z)-3-methyl-3-pentenyl diphosphate, which is not accepted as substrate by the enzyme, exhibited no inhibition on the synthase reaction | Bacillus subtilis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0085 | - |
isopentenyl diphosphate | 37°C, pH 37°C | Bacillus subtilis | |
0.0089 | - |
(2Z,6E,10E)-geranylgeranyl diphosphate | 37°C, pH 37°C | Bacillus subtilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Bacillus subtilis | kinetic experiments with artificial substrate homologues | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate | - |
Bacillus subtilis | 8 diphosphate + ditrans,octacis-undecaprenyl diphosphate | - |
? | |
(2Z,6E,10E)-geranylgeranyl diphosphate + isopentenyl diphosphate | - |
Bacillus subtilis | ? | - |
? | |
(E)-3-methyl-3-pentenyl diphosphate + isopentenyl diphosphate | reactive as substrate and competitive inhibition profile | Bacillus subtilis | ? | - |
? | |
additional information | kinetic experiments with artificial substrate homologues | Bacillus subtilis | ? | - |
? | |
additional information | Z-isomer ZHIPP, (Z)-3-methyl-3-pentenyl diphosphate, which is not accepted as substrate by the enzyme, exhibits no inhibition on the synthase reaction | Bacillus subtilis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
undecaprenyl diphosphate synthase | - |
Bacillus subtilis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bacillus subtilis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
assay at | Bacillus subtilis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0054 | - |
(2Z,6E,10E)-4-methyl-geranylgeranyl diphosphate | potent competitive inhibitor against (2Z,6E,10E)-geranylgeranyl diphosphate, 37°C, pH 37°C | Bacillus subtilis | |
0.0058 | - |
(2Z,6E,10E)-4-methyl-geranylgeranyl diphosphate | noncompetitive inhibitor against isopentenyl diphosphate, 37°C, pH 37°C | Bacillus subtilis | |
0.008 | - |
(2E,6E,10E)-4-methylfarnesyl diphosphate | competitive inhibitor against (2Z,6E,10E)-geranylgeranyl diphosphate, 37°C, pH 37°C | Bacillus subtilis | |
0.041 | - |
(E)-3-methyl-3-pentenyl diphosphate | calculated against isopentenyl diphosphate, 37°C, pH 37°C | Bacillus subtilis | |
0.075 | - |
(E)-3-methyl-3-pentenyl diphosphate | calculated against (2Z,6E,10E)-geranylgeranyl diphosphate, 37°C, pH 37°C | Bacillus subtilis |