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Literature summary for 2.5.1.29 extracted from

  • Foust, B.J.; Allen, C.; Holstein, S.A.; Wiemer, D.F.
    A new motif for inhibitors of geranylgeranyl diphosphate synthase (2016), Bioorg. Med. Chem., 24, 3734-3741.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.29

Inhibitors

Inhibitors Comment Organism Structure
((((6E,11E)-9-((((S)-3,7-dimethyloct-6-en-1-yl)oxy)((pivaloyloxy)methoxy)phosphoryl)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraen-9-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
 Homo sapiens
((((E)-1((((S)-3,7-dimethyloct-6-en-1-yl)oxy)((pialoxy)methoxy)phosphoryl)-4,8-dimethylnona-3,7-dien-1-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
 Homo sapiens
((((E)-2-((((R)-3,7-dimethyloct-6-en-1-yl)oxy)((pivaloyloxy)methoxy)phosphoryl)-5,9-dimethyldeca-4,8-dien-2-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
 Homo sapiens
((((E)-2-((((S)-3,7-dimethyloct-6-en-1-yl)oxy)((pivaloyloxy)methoxy)phosphoryl)-5,9-dimethyldeca-4,8-dien-2-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
 Homo sapiens
((((E)-4-((((S)-3,7-dimethyloct-6-en-1-yl)oxy)((pivaloyloxy)methoxy)phosphoryl)-7,11-dimethyldodeca-1,6,10-trien-4-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
 Homo sapiens
((((E)-5-((((S)-3,7-dimethyloct-6-en-1-yl)oxy)((pivaloyloxy)methoxy)phosphoryl)-2,8,12-trimethyltrideca-2,7,11-trien-5-yl)phosphoryl)bis(oxy))bis(methylene)bis(2,2-dimethylpropanoate)
-
 Homo sapiens
(3S)-3,7-dimethyloct-6-en-1-yl trimethyl [(6E)-2,6-dimethyldeca-2,6-diene-9,9-diyl]bis(phosphonate)
-
 Homo sapiens
(E)-dimethyl (4,8-dimethylnona-3,7-dien-1-yl)phosphonate
-
 Homo sapiens
(E)-methyl (4,8-dimethylnona-3,7-dien-1-yl)phosphonochloridate
-
 Homo sapiens
(R)-3,7-dimethyloct-6-en-1-yl methyl ((E)-1-(dimethoxyphosphoryl)-4,8-dimethylnona-3,7-dien-1-yl)phosphonate
-
 Homo sapiens
(R)-3,7-dimethyloct-6-en-1-yl methyl ((E)-2-(dimethoxyphosphoryl)-5,9-dimethyldeca-4,8-dien-2-yl)phosphonate
-
 Homo sapiens
(R)-3,7-dimethyloct-6-en-1-yl methyl ((E)-4,8-dimethylnona-3,7-dien-1-yl)phosphonate
-
 Homo sapiens
(S)-3,7-dimethyloct-6-en-1-yl methyl ((6E,11E)-9-(dimethoxyphosphoryl)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraen-9-yl)phosphonate
-
 Homo sapiens
(S)-3,7-dimethyloct-6-en-1-yl methyl ((E)-1-(dimethoxyphosphoryl)-4,8-dimethylnona-3,7-dien-1-yl)phosphonate
-
 Homo sapiens
(S)-3,7-dimethyloct-6-en-1-yl methyl ((E)-4,8-dimethylnona-3,7-dien-1-yl)phosphonate
-
 Homo sapiens
(S)-3,7-dimethyloct-6-en-1-yl methyl ((E)-4-(dimethoxyphosphoryl)-7,11-dimethyldodeca-1,6,10-trien-4-yl)phosphonate
-
 Homo sapiens
(S)-3,7-dimethyloct-6-en-1-yl methyl ((E)-5-(dimethoxyphosphoryl)-2,8,12-trimethyltrideca-2,7,11-trien-5-yl)phosphonate
-
 Homo sapiens
additional information pivaloyloxymethyl prodrugs of several compounds based on a motif , prepared with one isoprenoid chain on the alpha-carbon, a second included as a phosphonate ester, and the potential for a third at the alpha-carbon, are prepared and the resulting compounds are tested for their ability to disrupt protein geranylgeranylation and induce cytotoxicity in myeloma cells. The enzyme GGDPS inhibition demonstrate a structure–function relationship which is dependent on the nature of the alkyl group at the alpha-carbon. Cytotoxicity of the compounds in myeloma cells, overview Homo sapiens
pamidronate
-
 Homo sapiens
zoledronate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O95749
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myeloma cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
GGDPS
-
 Homo sapiens