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Literature summary for 2.5.1.29 extracted from

  • Jia, W.J.; Jiang, S.; Tang, Q.L.; Shen, D.; Xue, B.; Ning, W.; Li, C.J.
    Geranylgeranyl diphosphate synthase modulates fetal lung branching morphogenesis possibly through controlling K-Ras prenylation (2016), Am. J. Pathol., 186, 1454-1465.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information inducible lung epithelium-specific GGPS1 knockout mice (SPC-rtTA/TetO-Cre/Ggps1flox/flox) are generated by crossing Ggps1flox/flox mice with SPC-rtTA mice and TetOCre mice. All mice are backcrossed for at least six generations to C57BL/6J strain background and are genotyped by genomic DNA PCR Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q9WTN0 gene GGPS1
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Mus musculus C57/BL6J Q9WTN0 gene GGPS1
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Source Tissue

Source Tissue Comment Organism Textmining
epithelium
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Mus musculus
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lung
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Mus musculus
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Synonyms

Synonyms Comment Organism
geranylgeranyl diphosphate synthase 1
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Mus musculus
GGPPS
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Mus musculus
Ggps1
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Mus musculus

General Information

General Information Comment Organism
malfunction specific deletion of geranylgeranyl diphosphate synthase 1 (Ggps1) in lung epithelium during fetal lung development results in neonatal respiratory distress syndrome-like disease. The knockout mice die at postnatal day 1 of respiratory failure, and the lungs show compensatory pneumonectasis, pulmonary atelectasis, and hyaline membranes. Lung malformations in Ggps1-deficient mice result from the failure of fetal lung branching morphogenesis. Ggps1 deletion blocks K-Ras geranylgeranylation and extracellular signal-related kinase 1 or 2/mitogen-activated protein kinase signaling, which in turn disturbs fibroblast growth factor 10 regulation on fetal lung branching morphogenesis. Ggps1 deficiency inhibits KRas/MAPK signaling, which in turn abrogates FGF10 regulation on fetal lung morphogenesis, phenotype, overview Mus musculus
physiological function geranylgeranyl diphosphate synthase modulates fetal lung branching morphogenesis possibly through controlling K-Ras prenylation. Enzyme GGPPS-controlled K-Ras prenylation and Erk1/2/MAPK signaling mediates FGF signaling on lung branching morphogenesis. FGF10 signaling is a principal pathway in regulating the development of various organs, including lung, mammary gland, kidney, and prostate Mus musculus