Protein Variants | Comment | Organism |
---|---|---|
additional information | inducible lung epithelium-specific GGPS1 knockout mice (SPC-rtTA/TetO-Cre/Ggps1flox/flox) are generated by crossing Ggps1flox/flox mice with SPC-rtTA mice and TetOCre mice. All mice are backcrossed for at least six generations to C57BL/6J strain background and are genotyped by genomic DNA PCR | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9WTN0 | gene GGPS1 | - |
Mus musculus C57/BL6J | Q9WTN0 | gene GGPS1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
geranylgeranyl diphosphate synthase 1 | - |
Mus musculus |
GGPPS | - |
Mus musculus |
Ggps1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | specific deletion of geranylgeranyl diphosphate synthase 1 (Ggps1) in lung epithelium during fetal lung development results in neonatal respiratory distress syndrome-like disease. The knockout mice die at postnatal day 1 of respiratory failure, and the lungs show compensatory pneumonectasis, pulmonary atelectasis, and hyaline membranes. Lung malformations in Ggps1-deficient mice result from the failure of fetal lung branching morphogenesis. Ggps1 deletion blocks K-Ras geranylgeranylation and extracellular signal-related kinase 1 or 2/mitogen-activated protein kinase signaling, which in turn disturbs fibroblast growth factor 10 regulation on fetal lung branching morphogenesis. Ggps1 deficiency inhibits KRas/MAPK signaling, which in turn abrogates FGF10 regulation on fetal lung morphogenesis, phenotype, overview | Mus musculus |
physiological function | geranylgeranyl diphosphate synthase modulates fetal lung branching morphogenesis possibly through controlling K-Ras prenylation. Enzyme GGPPS-controlled K-Ras prenylation and Erk1/2/MAPK signaling mediates FGF signaling on lung branching morphogenesis. FGF10 signaling is a principal pathway in regulating the development of various organs, including lung, mammary gland, kidney, and prostate | Mus musculus |