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Literature summary for 2.5.1.29 extracted from

  • Weivoda, M.M.; Hohl, R.J.
    The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation (2011), J. Cell. Biochem., 112, 1506-1513.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
digeranyl bisphosphonate decreased intracellular GGPP levels in MC3T3-E1 pre-osteoblasts leading to impaired Rap1a geranylgeranylation. DGBP inhibits matrix mineralization in the MC3T3-E1 preosteoblasts Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate Mus musculus
-
diphosphate + geranylgeranyl diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MC3T3-E1 cell pre-osteoblast line Mus musculus
-
osteoblast
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
-
Mus musculus diphosphate + geranylgeranyl diphosphate
-
?

Synonyms

Synonyms Comment Organism
geranylgeranyl pyrophosphate synthase
-
Mus musculus
GGPP synthase
-
Mus musculus
GGPPS
-
Mus musculus

General Information

General Information Comment Organism
malfunction depletion of geranylgeranyl diphosphate by inhibitor statins leads to accumulation of farnesyl diphosphate, which activates nuclear hormone receptors stimulating osteoblast differentiation and bone formation. Statins directly inhibit HMG-CoA reductase, the first step of the isoprenoid biosynthesis pathway Mus musculus
physiological function the enzyme is required for synthesis of geranylgeranyl diphosphate which is required for e.g. Rap1a geranylgeranylation Mus musculus