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Literature summary for 2.5.1.29 extracted from
- Prenyltransferases of Bacillus subtilis: undecaprenyl pyrophosphate synthetase and geranylgeranyl pyrophosphate synthetase (1982), J. Biochem., 92, 1527-1537.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Triton X-100 | - |
Bacillus subtilis |  |
| Tween 80 | stimulates | Bacillus subtilis | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NH4+ | 20 mM, 20% inhibition | Bacillus subtilis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0133 | - |
geranyl diphosphate | - |
Bacillus subtilis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required for activity | Bacillus subtilis | |
| Mg2+ | optimal activity at 5 mM | Bacillus subtilis | |
| Mn2+ | activates | Bacillus subtilis | |
| Mn2+ | optimal activity at 0.5 mM | Bacillus subtilis | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 85000 | - |
gel filtration | Bacillus subtilis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (E,E)-farnesyl diphosphate + isopentenyl diphosphate | Bacillus subtilis | - |
geranylgeranyl diphosphate + diphosphate | - |
? | |
| dimethylallyl diphosphate + 3 isopentenyl diphosphate | Bacillus subtilis | - |
geranylgeranyl diphosphate + 3 diphosphate | - |
? | |
| geranyl diphosphate + 2 isopentenyl diphosphate | Bacillus subtilis | - |
geranylgeranyl diphosphate + 2 diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Bacillus subtilis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (E,E)-farnesyl diphosphate + isopentenyl diphosphate | - |
Bacillus subtilis | geranylgeranyl diphosphate + diphosphate | - |
? | |
| (E,E)-farnesyl diphosphate + isopentenyl diphosphate | - |
Bacillus subtilis | geranylgeranyl diphosphate + diphosphate | E,E)-geranylgeranyl diphosphate | ? | |
| dimethylallyl diphosphate + 3 isopentenyl diphosphate | - |
Bacillus subtilis | geranylgeranyl diphosphate + 3 diphosphate | - |
? | |
| geranyl diphosphate + 2 isopentenyl diphosphate | - |
Bacillus subtilis | geranylgeranyl diphosphate + 2 diphosphate | - |
? | |
| geranyl diphosphate + 2 isopentenyl diphosphate | - |
Bacillus subtilis | geranylgeranyl diphosphate + 2 diphosphate | E)-farnesyl diphosphate + (E,E,E)-geranylgeranyl diphosphate | ? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Bacillus subtilis |
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