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Literature summary for 2.5.1.26 extracted from

  • Zhu, Y.; Zhu, L.; Lu, L.; Zhang, L.; Zhang, G.; Wang, Q.; Yang, P.
    Role and mechanism of the alkylglycerone phosphate synthase in suppressing the invasion potential of human glioma and hepatic carcinoma cells in vitro (2014), Oncol. Rep., 32, 431-436.
    View publication on PubMed
Search for more literature for 2.5.1.26

Application

Application Comment Organism
medicine enzyme AGPS may be a potential glioma and hepatic carcinoma therapeutic target Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O00116
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-

Source Tissue

Source Tissue Comment Organism Textmining
glioma cell
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 Homo sapiens
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Hep-G2 cell
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 Homo sapiens
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hepatic carcinoma cell
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 Homo sapiens
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U-87 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
AGPS
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 Homo sapiens
alkylglycerone phosphate synthase
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 Homo sapiens

General Information

General Information Comment Organism
malfunction silencing of AGPS leads to reduced cellular level of lysophosphatidic acid, lysophosphatidic acid-ether and prostaglandin E2, which can fuel aggressive and progress of cancer. Effect of AGPS on adhesion, invasion and cell cycle of glioma and hepatic carcinoma cells, overview Homo sapiens
physiological function enzyme AGPS negatively regulates the invasion potential of glioma and hepatic carcinoma cells by modulating the expression of relevant genes and activity of the MAPK pathway. The MAPK signaling pathway is an important cell signaling pathway, involved in the regulation of many fundamental cellular processes Homo sapiens