Cloned (Comment) | Organism |
---|---|
two genes SQS, DA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis | Withania somnifera |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | associated enzyme with C-terminus anchored in the endoplasmic reticulum membrane and the N-terminus including active site is exposed in the cytosol | Withania somnifera | 5783 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Withania somnifera |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 (2E,6E)-farnesyl diphosphate + NADPH + H+ | Withania somnifera | - |
squalene + 2 diphosphate + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Withania somnifera | H9L9T8 | two genes | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 (2E,6E)-farnesyl diphosphate + NADPH + H+ | - |
Withania somnifera | squalene + 2 diphosphate + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SQS | - |
Withania somnifera |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Withania somnifera |
General Information | Comment | Organism |
---|---|---|
additional information | homology modelling of SQS enzyme of Withania somnifera for the prediction of three-dimensional structure, molecular docking study of considered substrates, overview | Withania somnifera |
physiological function | SQS play an important regulatory role in phytosterol biosynthetic pathway | Withania somnifera |