Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.21 extracted from

  • Tansey, T.R.; Shechter, I.
    Structure and regulation of mammalian squalene synthase (2000), Biochim. Biophys. Acta, 1529, 49-62.
    View publication on PubMed
Search for more literature for 2.5.1.21

Activating Compound

Activating Compound Comment Organism Structure
additional information overview on regulation Homo sapiens
additional information overview on regulation Rattus norvegicus
additional information overview on regulation Saccharomyces cerevisiae

Application

Application Comment Organism
medicine enzyme may be important during response to infection and inflammation Homo sapiens
medicine enzyme may be important during response to infection and inflammation Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
overview Homo sapiens
overview Rattus norvegicus
overview Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
farnesyl diphosphate + farnesyl diphosphate Saccharomyces cerevisiae
-
 diphosphate + presqualene diphosphate
-
 ?
farnesyl diphosphate + farnesyl diphosphate Homo sapiens enzyme may be important during response to infection and inflammation diphosphate + presqualene diphosphate
-
 ?
farnesyl diphosphate + farnesyl diphosphate Rattus norvegicus enzyme may be important during response to infection and inflammation diphosphate + presqualene diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ = squalene + 2 diphosphate + NAD(P)+ overview mechanism, kinetics Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate + farnesyl diphosphate
-
 Saccharomyces cerevisiae diphosphate + presqualene diphosphate
-
 ?
farnesyl diphosphate + farnesyl diphosphate enzyme may be important during response to infection and inflammation Homo sapiens diphosphate + presqualene diphosphate
-
 ?
farnesyl diphosphate + farnesyl diphosphate enzyme may be important during response to infection and inflammation Rattus norvegicus diphosphate + presqualene diphosphate
-
 ?