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Literature summary for 2.5.1.21 extracted from

  • Shechter, I.; Klinger, E.; Rucker, M.L.; Engstrom, R.G.; Spirito, J.A.; Islam, M.A.; Boettcher, B.R.; Weinstein, D.B.
    Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase (1992), J. Biol. Chem., 267, 8628-8635.
    View publication on PubMed
Search for more literature for 2.5.1.21

Application

Application Comment Organism
medicine induction of enzyme by a diet containing fluvastatin and cholestyramine Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
 trans-farnesyl diphosphate cosubstrate NADPH Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000 35000 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
trypsin-truncated enzyme Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate + NAD(P)H
-
 Rattus norvegicus squalene + diphosphate + NAD(P)+
-
 ?

Subunits

Subunits Comment Organism
? x * 32000-33000, trypsin-truncated enzyme, SDS-PAGE Rattus norvegicus