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Literature summary for 2.5.1.21 extracted from

  • Poulter, C.D.; Capson, T.L.; Thompson, M.D.; Bard, R.S.
    Squalene synthetase. Inhibition by ammonium analogues of carbocationic intermediates in the conversion of presqualene diphosphate to squalene (1989), J. Am. Chem. Soc., 111, 3734-3739.
No PubMed abstract available
Search for more literature for 2.5.1.21

Inhibitors

Inhibitors Comment Organism Structure
Ammonium analogues overview Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ = squalene + 2 diphosphate + NAD(P)+ mechanism Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate + farnesyl diphosphate
-
 Saccharomyces cerevisiae diphosphate + presqualene diphosphate
-
 ?
presqualene diphosphate + NAD(P)H a single active site catalyzes both reactions Saccharomyces cerevisiae squalene + NAD(P)+ + diphosphate
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Saccharomyces cerevisiae