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Literature summary for 2.5.1.18 extracted from

  • Heydel, J.M.; Menetrier, F.; Belloir, C.; Canon, F.; Faure, P.; Lirussi, F.; Chavanne, E.; Saliou, J.M.; Artur, Y.; Canivenc-Lavier, M.C.; Briand, L.; Neiers, F.
    Characterization of rat glutathione transferases in olfactory epithelium and mucus (2019), PLoS ONE, 14, e0220259 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
(+)-limonene oxide about 85% inhibition at 0.1 mM Rattus norvegicus
(-)-limonene oxide about 15% inhibition at 0.1 mM Rattus norvegicus
(R)-carvone about 8% inhibition at 0.1 mM Rattus norvegicus
2,4,6-trichloroanisole about 5% inhibition at 0.1 mM Rattus norvegicus
2-butanethiol about 2% inhibition at 0.01 mM Rattus norvegicus
beta-ionone about 15% inhibition at 0.1 mM Rattus norvegicus
cinnamaldehyde about 60% inhibition at 0.1 mM Rattus norvegicus
citral about 25% inhibition at 0.1 mM Rattus norvegicus
cyclohexanone about 3% inhibition at 0.1 mM Rattus norvegicus
Dimethyl sulfide about 5% inhibition at 0.1 mM Rattus norvegicus
geraniol about 3% inhibition at 0.1 mM Rattus norvegicus
geranyl acetate about 5% inhibition at 0.01 mM Rattus norvegicus
hexanoic acid about 5% inhibition at 0.1 mM Rattus norvegicus
limonene oxide about 70% inhibition at 0.1 mM Rattus norvegicus
mesityl oxide about 5% inhibition at 0.1 mM Rattus norvegicus
additional information not inhibited by 6-methyl-5-hepten-2-one Rattus norvegicus
S-carvone S-carvone inhibits 26% of the enzyme activity at 0.01 mM and 84% at 0.1 mM Rattus norvegicus
trans-2-hexen-1-al about 23% inhibition at 0.1 mM Rattus norvegicus
trans-2-nonenal about 23% inhibition at 0.01 mM Rattus norvegicus
Vanillin less than 10% inhibition at 0.1 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P08010
-
-

Purification (Commentary)

Purification (Comment) Organism
GST Trap column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
nasal mucosa
-
 Rattus norvegicus
-
olfactory epithelium
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 1-chloro-2,4-dinitrobenzene
-
 Rattus norvegicus chloride + 2,4-dinitrophenyl-glutathione
-
 ?

Subunits

Subunits Comment Organism
? x * about 30000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
glutathione S-transferase
-
 Rattus norvegicus
GSTM2 isoform Rattus norvegicus