Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bromosulfophthalein | non-competitive inhibition | Taenia crassiceps | |
Cibacron blue | non-competitive inhibition | Taenia crassiceps | |
haematin | non-competitive inhibition | Taenia crassiceps | |
indomethacin | uncompetitive inhibition | Taenia crassiceps | |
Rose bengal | non-competitive inhibition | Taenia crassiceps |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
glutathione | isoform GST2, at pH 7.5 and 25°C | Taenia crassiceps | |
0.55 | - |
glutathione | isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | |
0.86 | - |
1-chloro-2,4-dinitrobenzene | isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | |
1.03 | - |
1-chloro-2,4-dinitrobenzene | isoform GST2, at pH 7.5 and 25°C | Taenia crassiceps |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54000 | - |
isoform GST1, gel filtration | Taenia crassiceps |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Taenia crassiceps | - |
- |
- |
Purification (Comment) | Organism |
---|---|
glutathione-Sepharose column chromatography | Taenia crassiceps |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cysticercus | - |
Taenia crassiceps | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.12 | - |
isoform GST1, with trans-trans-2,4-nonadienal as substrate, at pH 8.5 and 25°C | Taenia crassiceps |
1.27 | - |
isoform GST2, with trans-trans-2,4-hexadienal as substrate, at pH 8.5 and 25°C | Taenia crassiceps |
1.31 | - |
isoform GST1, with trans-trans-2,4-hexadienal as substrate, at pH 8.5 and 25°C | Taenia crassiceps |
1.4 | - |
isoform GST2, with 1,2-dichloro-4,5-dinitrobenzene as substrate, at pH 8.5 and 25°C | Taenia crassiceps |
1.49 | - |
isoform GST2, with trans-trans-2,4-decadienal as substrate, at pH 8.5 and 25°C | Taenia crassiceps |
1.51 | - |
isoform GST2, with trans-trans-2,4-nonadienal as substrate, at pH 8.5 and 25°C | Taenia crassiceps |
1.91 | - |
isoform GST1, with trans-trans-2,4-decadienal as substrate, at pH 8.5 and 25°C | Taenia crassiceps |
2 | - |
isoform GST1, with 1,2-dichloro-4,5-dinitrobenzene as substrate, at pH 8.5 and 25°C | Taenia crassiceps |
19.4 | - |
isoform GST2, with 1-chloro-2,4-dinitrobenzene as substrate, at pH 8.5 and 25°C | Taenia crassiceps |
26.9 | - |
isoform GST1, with 1-chloro-2,4-dinitrobenzene as substrate, at pH 8.5 and 25°C | Taenia crassiceps |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + 1,2-dichloro-4,5-dinitrobenzene | - |
Taenia crassiceps | ? | - |
? | |
glutathione + 1,2-dichloro-4-nitrobenzene | - |
Taenia crassiceps | ? | - |
? | |
glutathione + 1-chloro-2,4-dinitrobenzene | - |
Taenia crassiceps | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
glutathione + trans-trans-2,4-decadienal | - |
Taenia crassiceps | ? | - |
? | |
glutathione + trans-trans-2,4-hexadienal | - |
Taenia crassiceps | ? | - |
? | |
glutathione + trans-trans-2,4-nonadienal | - |
Taenia crassiceps | ? | - |
? | |
additional information | bromosulfophthalein, 1,2-epoxy-3-(4-nitrophenoxy) propane and ethacrynic acid do not act as substrates | Taenia crassiceps | ? | - |
- |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 26800, isoform GST2, SDS-PAGE | Taenia crassiceps |
homodimer | 2 * 27500, isoform GST1, SDS-PAGE | Taenia crassiceps |
Synonyms | Comment | Organism |
---|---|---|
GST1 | isoform | Taenia crassiceps |
GST2 | isoform | Taenia crassiceps |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
35 | - |
isoform GST1 | Taenia crassiceps |
40 | - |
isoform GST2 | Taenia crassiceps |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | 55 | isoform GST1 shows more than 80% activity between 20 and 55°C | Taenia crassiceps |
25 | 45 | isoform GST2 shows more than 50% activity between 25 and 45°C | Taenia crassiceps |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | 45 | the transferase activity of isoform GST2 is stable from 30 to 45°C but disappears quickly at higher temperatures. Additionally, the enzyme isoforms GST1 and GST2 are stable at 20°C and 37°C for 30 min | Taenia crassiceps |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.99 | - |
1-chloro-2,4-dinitrobenzene | isoform GST2, at pH 7.5 and 25°C | Taenia crassiceps | |
2.96 | - |
glutathione | isoform GST2, at pH 8.5 and 25°C | Taenia crassiceps | |
9.63 | - |
glutathione | isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | |
62.5 | - |
1-chloro-2,4-dinitrobenzene | isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
isoform GST2 | Taenia crassiceps |
8.5 | - |
isoform GST1 | Taenia crassiceps |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000508 | - |
haematin | isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | |
0.02 | - |
indomethacin | isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | |
0.3 | - |
Cibacron blue | isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | |
2.7 | - |
Rose bengal | isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | |
13 | - |
bromosulfophthalein | isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00053 | - |
isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | haematin | |
0.0009 | - |
isoform GST2, at pH 8.5 and 25°C | Taenia crassiceps | Cibacron blue | |
0.0014 | - |
isoform GST2, at pH 8.5 and 25°C | Taenia crassiceps | indomethacin | |
0.008 | - |
isoform GST2, at pH 8.5 and 25°C | Taenia crassiceps | Rose bengal | |
0.0107 | - |
isoform GST2, at pH 8.5 and 25°C | Taenia crassiceps | bromosulfophthalein | |
0.034 | - |
isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | Rose bengal | |
0.2 | - |
isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | indomethacin | |
1.6 | - |
isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | bromosulfophthalein | |
2 | - |
isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | Cibacron blue |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.9 | - |
1-chloro-2,4-dinitrobenzene | isoform GST2, at pH 7.5 and 25°C | Taenia crassiceps | |
9.8 | - |
glutathione | isoform GST2, at pH 8.5 and 25°C | Taenia crassiceps | |
17.5 | - |
glutathione | isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps | |
72 | - |
1-chloro-2,4-dinitrobenzene | isoform GST1, at pH 8.5 and 25°C | Taenia crassiceps |