Application | Comment | Organism |
---|---|---|
medicine | dichloroacetate, a degradation product of chloral hydrate, is further metabolized by glutathione transferase zeta 1, and inhibits its own metabolism through depletion/inactivation of GSTZ1/MAAI with repeated exposure, resulting in lower plasma clearance of the drug and the accumulation of the urinary biomarker maleylacetone. The amount of dichloroacetate produced from clinically relevant doses of chloral hydrate, although insufficient to alter dichloroacetate kinetics, is sufficient to inhibit MAAI and tyrosine catabolism | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O43708 | bifunctional enzyme, catalyzes reactions of maleylacetoacetate isomerase, EC 5.2.1.2 and of EC 2.5.1.18 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dichloroacetate + glutathione | - |
Homo sapiens | 2-(glutathion-S-yl)-chloroacetate + HCl | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione transferase zeta 1 | - |
Homo sapiens |
Gstz1 | - |
Homo sapiens |
MAAI | - |
Homo sapiens |
More | maleylacetoacetate isomerase, EC 5.2.1.2, bifunctional enzyme | Homo sapiens |