Application | Comment | Organism |
---|---|---|
medicine | the GST isozymes are useful as vaccine against hookworm infection | Necator americanus |
Cloned (Comment) | Organism |
---|---|
genes Na-gst-1, Na-gst-2, and Na-gst-3, encoding isozymes GST-1, GST-2, and GST-3, phylogenetic analysis, recombinant expression in Pichia pastoris, the recombinant isozymes all exhibit low lipid peroxidase and glutathione-conjugating enzymatic activities but high heme-binding capacities | Necator americanus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Hematin | binding by isozymes with high affinity | Necator americanus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Necator americanus | D3U1A5 | genes Na-gst-1, Na-gst-2, and Na-gst-3 encoding isozymes GST-1, GST-2, and GST-3 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + 1-chloro-2,4-dinitrobenzene | - |
Necator americanus | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
additional information | recombinant isozymes GST-1, GST-2, and GST-3, expressed in Pichia pastoris, all exhibit low lipid peroxidase and glutathione-conjugating enzymatic activities but high heme-binding capacities | Necator americanus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione S-transferase | - |
Necator americanus |
GST | - |
Necator americanus |
More | the Necator americanus GST isozymes belong to a nematode-specific nu-class GST family | Necator americanus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Necator americanus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Necator americanus |
General Information | Comment | Organism |
---|---|---|
physiological function | the isozymes may be involved in the detoxification and/or transport of heme | Necator americanus |