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Literature summary for 2.5.1.18 extracted from

  • Whalen, R.; Kempner, E.S.; Boyer, T.D.
    Structural studies of a human pi class glutathione S-transferase. Photoaffinity labeling of the active site and target size analysis (1996), Biochem. Pharmacol., 52, 281-288.
    View publication on PubMed
Search for more literature for 2.5.1.18

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
S-(4-azidophenacryl)-glutathione competitive inhibitor, 27% loss of activity after 5 min Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.09
-
 glutathione recombinant enzyme Homo sapiens
0.22
-
 glutathione placental enzyme Homo sapiens
2.57
-
 1-chloro-2,4-dinitrobenzene placental enzyme Homo sapiens
6.6
-
 1-chloro-2,4-dinitrobenzene recombinant enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
GST pi Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Homo sapiens
-
skin
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0029 0.0036 with 1-chloro-2,4-dinitrobenzene as substrate Homo sapiens
0.84 0.92 with glutathione as substrate Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 1-chloro-2,4-dinitrobenzene
-
 Homo sapiens S-2,4-dinitrophenylglutathione + HCl
-
 ?
glutathione + ethacrynic acid
-
 Homo sapiens ?
-
 ?