Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.18 extracted from

  • Berhane, K.; Widersten, M.; Engstroem, A.; Kozarich, J.W.; Mannervik, B.
    Detoxication of base propenals and other alpha,beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases (1994), Proc. Natl. Acad. Sci. USA, 91, 1480-1484.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
S-hexylglutathione
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
P1-1, A1-1 and M1-1 Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.7
-
with adenine propenal, isoenzyme A1-1 Homo sapiens
0.86
-
with acrolein, isoenzyme A1-1 Homo sapiens
3.7
-
with adenine propenal, isoenzyme M1-1 Homo sapiens
7.05
-
with acrolein, isoenzyme M1-1 Homo sapiens
26.3
-
with acrolein, isoenzyme P1-1 Homo sapiens
77
-
with adenine propenal, isoenzyme P1-1 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + acrolein
-
Homo sapiens ?
-
?
glutathione + adenine propenal
-
Homo sapiens ?
-
?
additional information conjugation of glutathione with base propenals and related alkenes, A1-1 and M1-1 are more active with 4-hydroxyalkenals than with base propenals Homo sapiens ?
-
?