Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N-ethylmaleimide | 8fold | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0006 | - |
glutathione | not activated | Rattus norvegicus | |
0.001 | 0.002 | glutathione | activated with N-ethylmaleimide | Rattus norvegicus | |
0.006 | - |
1-chloro-2,4-dinitrobenzene | not activated | Rattus norvegicus | |
0.03 | - |
1-chloro-2,4-dinitrobenzene | activated with N-ethylmaleimide | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | exposed on cytoplasmic surface | Rattus norvegicus | 5783 | - |
microsome | - |
Rattus norvegicus | - |
- |
additional information | microsomal enzyme is clearly distinct from cytosolic | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
RX + glutathione | Rattus norvegicus | microsomal enzyme is likely to be involved in drug metabolism | HX + R-S-glutathione | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + 1,2-dichloro-4-nitrobenzene | at a low rate | Rattus norvegicus | ? | - |
? | |
glutathione + 1-chloro-2,4-dinitrobenzene | - |
Rattus norvegicus | S-2,4-dinitrophenylglutathione + HCl | - |
? | |
RX + glutathione | RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange | Rattus norvegicus | HX + R-S-glutathione | - |
? | |
RX + glutathione | microsomal enzyme is likely to be involved in drug metabolism | Rattus norvegicus | HX + R-S-glutathione | - |
? |