Literature summary for 2.5.1.17 extracted from

Stich, T.A.; Yamanishi, M.; Banerjee, R.; Brunold, T.C.
Spectroscopic evidence for the formation of a four-coordinate Co2+ cobalamin species upon binding to the human ATP:cobalamin adenosyltransferase (2005), J. Am. Chem. Soc., 127, 7660-7661.

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Activating Compound

Activating Compound	Comment	Organism	Structure
ATP	induces formation of activated Co2+ species	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + cob(I)alamin	reaction mechanism: assimilated cobalamin is reduced to co(II)alamin, that then binds to the enzyme-ATP complex, further reduction yields a nucleophilic four coordinated Co1+ intermediate that attacks the 5'-carbon of the cosubstrate ATP to generate adenosylcobalamin and triphosphate, spectroscopic analysis, enzyme-induced base-on/base-off conversion activating the cobalamin substrate for reduction	Homo sapiens	triphosphate + adenosylcob(III)alamin	-	ir

Synonyms

Synonyms	Comment	Organism
ATP:cobalamin adenosyltransferase	-	Homo sapiens
ATR	-	Homo sapiens

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Release 2023.1 (January 2023)