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Literature summary for 2.5.1.15 extracted from

  • Bacon, D.; Tang, D.; Salas, C.; Roncal, N.; Lucas, C.; Gerena, L.; Tapia, L.; Llanos-Cuentas, A.; Garcia, C.; Solari, L.; Kyle, D.; Magill, A.
    Effects of point mutations in Plasmodium falciparum dihydrofolate reductase and dihydropterate synthase genes on clinical outcomes and in vitro susceptibility to sulfadoxine and pyrimethamine (2009), PLoS ONE, 4, e6762.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
K540E correlation of polymorphisms in Plasmodium falciparum dihydropteroate synthase and in vitro parasite susceptibility to sulfadoxine and pyrimethamine and in vivo treatment are analyzed: Patients with the dihydropteroate synthase K540E mutation are 2.6times as likely to fail treatment compared to patients having wild-type form form Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
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-
-

Synonyms

Synonyms Comment Organism
DHPS
-
Plasmodium falciparum
dihydropteroate synthase
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Plasmodium falciparum