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Literature summary for 2.5.1.15 extracted from

  • Vinnicombe, H.G.; Derrick, J.P.
    Dihydropteroate synthase from Streptococcus pneumoniae: characterization of substrate binding order and sulfonamide inhibition (1999), Biochem. Biophys. Res. Commun., 258, 752-757.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Streptococcus pneumoniae

Inhibitors

Inhibitors Comment Organism Structure
dihydrofolate
-
Streptococcus pneumoniae
folate
-
Streptococcus pneumoniae
sulfamethoxazole
-
Streptococcus pneumoniae
sulfanilamide
-
Streptococcus pneumoniae
sulfaquinoxazoline
-
Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Streptococcus pneumoniae
-
diphosphate + 7,8-dihydropteroate
-
?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Superdex-200 HR and other chromatographic columns Streptococcus pneumoniae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.29
-
-
Streptococcus pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Streptococcus pneumoniae diphosphate + 7,8-dihydropteroate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00059
-
sulfamethoxazole
-
Streptococcus pneumoniae
0.00085
-
sulfanilamide
-
Streptococcus pneumoniae
0.015
-
folate
-
Streptococcus pneumoniae
0.025
-
sulfaquinoxazoline
-
Streptococcus pneumoniae