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Literature summary for 2.5.1.15 extracted from

  • Shiota, T.; Baugh, C.M.; Jackson, R.; Dillard, R.
    The enzymatic synthesis of hydroxymethyldihydropteridine pyrophosphate and dihydrofolate (1969), Biochemistry, 8, 5022-5028.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
p-aminobenzoylglutamate weak Lactiplantibacillus plantarum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required to synthesize product Lactiplantibacillus plantarum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Lactiplantibacillus plantarum
-
diphosphate + 7,8-dihydropteroate
-
?
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoylglutamate Lactiplantibacillus plantarum
-
diphosphate + dihydrofolate
-
?

Organism

Organism UniProt Comment Textmining
Lactiplantibacillus plantarum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
precipitation with ammonium sulfate followed by column chromatography Lactiplantibacillus plantarum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Lactiplantibacillus plantarum diphosphate + 7,8-dihydropteroate
-
?
2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoylglutamate
-
Lactiplantibacillus plantarum diphosphate + dihydrofolate
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
10 min, loss of activity Lactiplantibacillus plantarum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1
-
p-aminobenzoylglutamate
-
Lactiplantibacillus plantarum