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Literature summary for 2.5.1.120 extracted from

  • Joshi, S.; Fedoseyenko, D.; Mahanta, N.; Ducati, R.G.; Feng, M.; Schramm, V.L.; Begley, T.P.
    Antibacterial strategy against H. pylori Inhibition of the radical SAM enzyme MqnE in menaquinone biosynthesis (2019), ACS Med. Chem. Lett., 10, 363-366 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.120

Inhibitors

Inhibitors Comment Organism Structure
3-(2-carboxyprop-2-en-1-yl)benzoic acid
-
 Campylobacter jejuni
3-(2-carboxyprop-2-en-1-yl)benzoic acid
-
 Helicobacter pylori
9-[8-[(3-carboxyphenyl)methyl]-5,6,7,8-tetradeoxy-beta-D-ribo-nonofuranuronosyl]-9H-purin-6-amine
-
 Campylobacter jejuni
9-[8-[(3-carboxyphenyl)methyl]-5,6,7,8-tetradeoxy-beta-D-ribo-nonofuranuronosyl]-9H-purin-6-amine
-
 Helicobacter pylori
butylthio-DADMe-immucillin-A
-
 Campylobacter jejuni
butylthio-DADMe-immucillin-A
-
 Helicobacter pylori
gentamicin
-
 Campylobacter jejuni
gentamicin
-
 Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O Campylobacter jejuni
-
 6-amino-6-deoxyfutalosine + L-methionine + HCO3-
-
 ?
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O Helicobacter pylori
-
 6-amino-6-deoxyfutalosine + L-methionine + HCO3-
-
 ?
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O Helicobacter pylori ATCC 700392
-
 6-amino-6-deoxyfutalosine + L-methionine + HCO3-
-
 ?

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni
-
-
-
Helicobacter pylori O25368
-
-
Helicobacter pylori ATCC 700392 O25368
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O
-
 Campylobacter jejuni 6-amino-6-deoxyfutalosine + L-methionine + HCO3-
-
 ?
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O
-
 Helicobacter pylori 6-amino-6-deoxyfutalosine + L-methionine + HCO3-
-
 ?
S-adenosyl-L-methionine + 3-[(1-carboxyvinyl)oxy]benzoate + H2O
-
 Helicobacter pylori ATCC 700392 6-amino-6-deoxyfutalosine + L-methionine + HCO3-
-
 ?

Synonyms

Synonyms Comment Organism
MqnE
-
 Campylobacter jejuni
MqnE
-
 Helicobacter pylori

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Campylobacter jejuni
S-adenosyl-L-methionine
-
 Helicobacter pylori

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0018
-
 pH and temperature not specified in the publication Helicobacter pylori 3-(2-carboxyprop-2-en-1-yl)benzoic acid
0.0136
-
 pH and temperature not specified in the publication Campylobacter jejuni 3-(2-carboxyprop-2-en-1-yl)benzoic acid
0.0161
-
 pH and temperature not specified in the publication Helicobacter pylori 9-[8-[(3-carboxyphenyl)methyl]-5,6,7,8-tetradeoxy-beta-D-ribo-nonofuranuronosyl]-9H-purin-6-amine
0.0833
-
 pH and temperature not specified in the publication Campylobacter jejuni 9-[8-[(3-carboxyphenyl)methyl]-5,6,7,8-tetradeoxy-beta-D-ribo-nonofuranuronosyl]-9H-purin-6-amine