Literature summary for 2.5.1.108 extracted from

Dong, M.; Horitani, M.; Dzikovski, B.; Freed, J.; Ealick, S.; Hoffman, B.; Lin, H.
Substrate-dependent cleavage site selection by unconventional radical S-adenosylmethionine enzymes in diphthamide biosynthesis (2017), J. Am. Chem. Soc., 139, 5680-5683 .

Search for more literature for 2.5.1.108

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5'-deoxy-5'-(3-(3-N,N-dimethylamino)phenoxy)propyl-5'-methyl-5'-thioadenosine + a protein	Pyrococcus horikoshii	-	5'-deoxy-5'-(3-(3-N,N-dimethylamino)phenoxy)propyl-5'-thioadenosine + a methylated protein	-	?
5'-deoxy-5'-(3-phenoxy)propyl-5'-methyl-5'-thioadenosine + a protein	Pyrococcus horikoshii	-	5'-deoxy-5'-(3-phenoxy)propyl-5'-thioadenosine + a methylated protein	-	?
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]	Pyrococcus horikoshii	-	S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Pyrococcus horikoshii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5'-deoxy-5'-(3-(3-N,N-dimethylamino)phenoxy)propyl-5'-methyl-5'-thioadenosine + a protein	-	Pyrococcus horikoshii	5'-deoxy-5'-(3-(3-N,N-dimethylamino)phenoxy)propyl-5'-thioadenosine + a methylated protein	-	?
5'-deoxy-5'-(3-phenoxy)propyl-5'-methyl-5'-thioadenosine + a protein	-	Pyrococcus horikoshii	5'-deoxy-5'-(3-phenoxy)propyl-5'-thioadenosine + a methylated protein	-	?
S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2]	-	Pyrococcus horikoshii	S-methyl-5'-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2]	-	?

Subunits

Subunits	Comment	Organism
homodimer	2 * 40000, SDS-PAGE	Pyrococcus horikoshii

Synonyms

Synonyms	Comment	Organism
Dph2	-	Pyrococcus horikoshii

Cofactor

Cofactor	Comment	Organism	Structure
[4Fe-4S]-center	-	Pyrococcus horikoshii

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)