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Literature summary for 2.5.1.108 extracted from

  • Dong, M.; Horitani, M.; Dzikovski, B.; Pandelia, M.E.; Krebs, C.; Freed, J.H.; Hoffman, B.M.; Lin, H.
    An organometallic complex formed by an unconventional radical SAM enzyme (2016), J. Am. Chem. Soc., 138, 9755-9758.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.108

Organism

Organism UniProt Comment Textmining
Pyrococcus horikoshii O58832
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-histidine-[translation elongation factor 2] + S-adenosyl-L-methionine
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 Pyrococcus horikoshii 2-((3S)-3-amino-3-carboxypropyl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
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 ?
L-histidine-[translation elongation factor 2] + [[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl][(2E)-3-carboxyprop-2-en-1-yl]methylsulfonium S-adenosyl-L-methionine analogue, in which the 3-amino-3-carboxypropyl group is replaced with a 3-carboxyallyl group. The analogue is cleaved by Dph2, yielding a paramagnetic (S = 1/2) species, which is assigned to a complex formed between the reaction product, alpha-sulfinyl-3-butenoic acid, and the [4Fe-4S] cluster. Data support a pi-complex between the C=C double bond of alpha-sulfinyl-3-butenoic acid and the unique iron of the [4Fe-4S] cluster, i.e. a radical S-adenosyl-L-methionine-related [4Fe-4S]+ cluster forming an organometallic complex with an alkene Pyrococcus horikoshii 2-(3-carboxyprop-2-en-1-yl)-L-histidine-[translation elongation factor 2] + S-methyl-5'-thioadenosine
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 ?

Synonyms

Synonyms Comment Organism
Dph2
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 Pyrococcus horikoshii

Cofactor

Cofactor Comment Organism Structure
[4Fe-4S]-center cleavage of a S-adenosyl-L-methionine analogue, in which the 3-amino-3-carboxypropyl group is replaced with a 3-carboxyallyl group, yields a paramagnetic (S = 1/2) species, which is assigned to a complex formed between the reaction product, alpha-sulfinyl-3-butenoic acid, and the [4Fe-4S] cluster. Data support a pi-complex between the C=C double bond of alpha-sulfinyl-3-butenoic acid and the unique iron of the [4Fe-4S] cluster, i.e. a radical S-adenosyl-L-methionine-related [4Fe-4S]+ cluster forming an organometallic complex with an alkene Pyrococcus horikoshii