Crystallization (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, using 1.2 M phosphate buffer (pH 5.0), 25% (v/v) glycerol | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,4aS,6aS,12bR,14aS)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid | - |
Trypanosoma brucei | |
1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid | - |
Homo sapiens | |
1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid | - |
Trypanosoma brucei | |
11-hydroxyabieta-7,9(11),13-triene-6,12-dione | - |
Homo sapiens | |
2,6,7-trihydroxy-9-(2-hydroxyphenyl)-4,4a-dihydro-3H-xanthen-3-one | - |
Homo sapiens | |
2,6,7-trihydroxy-9-(2-hydroxyphenyl)-4,4a-dihydro-3H-xanthen-3-one | - |
Trypanosoma brucei | |
2-[[(1S,2R,4aR)-4a-hydroxy-1,2-dimethyl-5-methylidenedecahydronaphthalen-1-yl]methyl]cyclohexa-2,5-diene-1,4-dione | - |
Homo sapiens | |
arenarone | - |
Homo sapiens | |
arenarone | - |
Trypanosoma brucei | |
celastrol | - |
Homo sapiens | |
celastrol | - |
Trypanosoma brucei | |
taxodione | - |
Homo sapiens | |
taxodione | - |
Trypanosoma brucei | |
taxodone | - |
Homo sapiens | |
taxodone | - |
Trypanosoma brucei | |
zoledronate | - |
Homo sapiens | |
zoledronate | - |
Trypanosoma brucei |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranyl diphosphate + isopentenyl diphosphate | Trypanosoma brucei | - |
diphosphate + (2E,6E)-farnesyl diphosphate | - |
? | |
geranyl diphosphate + isopentenyl diphosphate | Homo sapiens | - |
diphosphate + (2E,6E)-farnesyl diphosphate | - |
? | |
isopentenyl diphosphate + dimethylallyl diphosphate | Trypanosoma brucei | - |
diphosphate + geranyl diphosphate | - |
? | |
isopentenyl diphosphate + dimethylallyl diphosphate | Homo sapiens | - |
diphosphate + geranyl diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14324 | - |
- |
Trypanosoma brucei | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
geranyl diphosphate + isopentenyl diphosphate | - |
Trypanosoma brucei | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? | |
geranyl diphosphate + isopentenyl diphosphate | - |
Homo sapiens | diphosphate + (2E,6E)-farnesyl diphosphate | - |
? | |
isopentenyl diphosphate + dimethylallyl diphosphate | - |
Trypanosoma brucei | diphosphate + geranyl diphosphate | - |
? | |
isopentenyl diphosphate + dimethylallyl diphosphate | - |
Homo sapiens | diphosphate + geranyl diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
farnesyl pyrophosphate synthase | - |
Trypanosoma brucei |
farnesyl pyrophosphate synthase | - |
Homo sapiens |
FPPS | - |
Trypanosoma brucei |
FPPS | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0011 | - |
pH and temperature not specified in the publication | Homo sapiens | arenarone | |
0.0011 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[[(1S,2R,4aR)-4a-hydroxy-1,2-dimethyl-5-methylidenedecahydronaphthalen-1-yl]methyl]cyclohexa-2,5-diene-1,4-dione | |
0.0012 | - |
pH and temperature not specified in the publication | Homo sapiens | taxodione | |
0.0012 | - |
pH and temperature not specified in the publication | Homo sapiens | 11-hydroxyabieta-7,9(11),13-triene-6,12-dione | |
0.0024 | - |
pH and temperature not specified in the publication | Homo sapiens | taxodone | |
0.0024 | - |
pH and temperature not specified in the publication | Homo sapiens | 11-hydroxyabieta-7,9(11),13-triene-6,12-dione | |
0.0171 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | celastrol | |
0.0171 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | (2R,4aS,6aS,12bR,14aS)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid | |
0.0173 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | taxodione | |
0.0278 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | arenarone | |
0.0431 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | taxodone | |
0.054 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 2,6,7-trihydroxy-9-(2-hydroxyphenyl)-4,4a-dihydro-3H-xanthen-3-one | |
0.0542 | - |
pH and temperature not specified in the publication | Trypanosoma brucei | 1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid | |
0.081 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid | |
0.081 | - |
pH and temperature not specified in the publication | Homo sapiens | 2,6,7-trihydroxy-9-(2-hydroxyphenyl)-4,4a-dihydro-3H-xanthen-3-one | |
0.2 | - |
IC50 above 0.2 mM, pH and temperature not specified in the publication | Homo sapiens | celastrol |