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Literature summary for 2.5.1.10 extracted from

  • Liu, Y.L.; Lindert, S.; Zhu, W.; Wang, K.; McCammon, J.A.; Oldfield, E.
    Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site (2014), Proc. Natl. Acad. Sci. USA, 111, E2530-E2539.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, using 1.2 M phosphate buffer (pH 5.0), 25% (v/v) glycerol Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2R,4aS,6aS,12bR,14aS)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
-
Trypanosoma brucei
1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid
-
Homo sapiens
1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid
-
Trypanosoma brucei
11-hydroxyabieta-7,9(11),13-triene-6,12-dione
-
Homo sapiens
2,6,7-trihydroxy-9-(2-hydroxyphenyl)-4,4a-dihydro-3H-xanthen-3-one
-
Homo sapiens
2,6,7-trihydroxy-9-(2-hydroxyphenyl)-4,4a-dihydro-3H-xanthen-3-one
-
Trypanosoma brucei
2-[[(1S,2R,4aR)-4a-hydroxy-1,2-dimethyl-5-methylidenedecahydronaphthalen-1-yl]methyl]cyclohexa-2,5-diene-1,4-dione
-
Homo sapiens
arenarone
-
Homo sapiens
arenarone
-
Trypanosoma brucei
celastrol
-
Homo sapiens
celastrol
-
Trypanosoma brucei
taxodione
-
Homo sapiens
taxodione
-
Trypanosoma brucei
taxodone
-
Homo sapiens
taxodone
-
Trypanosoma brucei
zoledronate
-
Homo sapiens
zoledronate
-
Trypanosoma brucei

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranyl diphosphate + isopentenyl diphosphate Trypanosoma brucei
-
diphosphate + (2E,6E)-farnesyl diphosphate
-
?
geranyl diphosphate + isopentenyl diphosphate Homo sapiens
-
diphosphate + (2E,6E)-farnesyl diphosphate
-
?
isopentenyl diphosphate + dimethylallyl diphosphate Trypanosoma brucei
-
diphosphate + geranyl diphosphate
-
?
isopentenyl diphosphate + dimethylallyl diphosphate Homo sapiens
-
diphosphate + geranyl diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14324
-
-
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranyl diphosphate + isopentenyl diphosphate
-
Trypanosoma brucei diphosphate + (2E,6E)-farnesyl diphosphate
-
?
geranyl diphosphate + isopentenyl diphosphate
-
Homo sapiens diphosphate + (2E,6E)-farnesyl diphosphate
-
?
isopentenyl diphosphate + dimethylallyl diphosphate
-
Trypanosoma brucei diphosphate + geranyl diphosphate
-
?
isopentenyl diphosphate + dimethylallyl diphosphate
-
Homo sapiens diphosphate + geranyl diphosphate
-
?

Synonyms

Synonyms Comment Organism
farnesyl pyrophosphate synthase
-
Trypanosoma brucei
farnesyl pyrophosphate synthase
-
Homo sapiens
FPPS
-
Trypanosoma brucei
FPPS
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0011
-
pH and temperature not specified in the publication Homo sapiens arenarone
0.0011
-
pH and temperature not specified in the publication Homo sapiens 2-[[(1S,2R,4aR)-4a-hydroxy-1,2-dimethyl-5-methylidenedecahydronaphthalen-1-yl]methyl]cyclohexa-2,5-diene-1,4-dione
0.0012
-
pH and temperature not specified in the publication Homo sapiens taxodione
0.0012
-
pH and temperature not specified in the publication Homo sapiens 11-hydroxyabieta-7,9(11),13-triene-6,12-dione
0.0024
-
pH and temperature not specified in the publication Homo sapiens taxodone
0.0024
-
pH and temperature not specified in the publication Homo sapiens 11-hydroxyabieta-7,9(11),13-triene-6,12-dione
0.0171
-
pH and temperature not specified in the publication Trypanosoma brucei celastrol
0.0171
-
pH and temperature not specified in the publication Trypanosoma brucei (2R,4aS,6aS,12bR,14aS)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid
0.0173
-
pH and temperature not specified in the publication Trypanosoma brucei taxodione
0.0278
-
pH and temperature not specified in the publication Trypanosoma brucei arenarone
0.0431
-
pH and temperature not specified in the publication Trypanosoma brucei taxodone
0.054
-
pH and temperature not specified in the publication Trypanosoma brucei 2,6,7-trihydroxy-9-(2-hydroxyphenyl)-4,4a-dihydro-3H-xanthen-3-one
0.0542
-
pH and temperature not specified in the publication Trypanosoma brucei 1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid
0.081
-
pH and temperature not specified in the publication Homo sapiens 1-(carboxymethyl)-1H-benzo[g]indole-2-carboxylic acid
0.081
-
pH and temperature not specified in the publication Homo sapiens 2,6,7-trihydroxy-9-(2-hydroxyphenyl)-4,4a-dihydro-3H-xanthen-3-one
0.2
-
IC50 above 0.2 mM, pH and temperature not specified in the publication Homo sapiens celastrol