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Literature summary for 2.5.1.10 extracted from

  • Szajnman, S.H.; Garcia Linares, G.E.; Li, Z.H.; Jiang, C.; Galizzi, M.; Bontempi, E.J.; Ferella, M.; Moreno, S.N.; Docampo, R.; Rodriguez, J.B.
    Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase (2008), Bioorg. Med. Chem., 16, 3283-3290.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.10

Inhibitors

Inhibitors Comment Organism Structure
1-[(n-hept-1-ylamino)ethyl] 1,1-bisphosphonic acid
-
 Toxoplasma gondii
1-[(n-hept-1-ylamino)ethyl] 1,1-bisphosphonic acid
-
 Trypanosoma cruzi
1-[(n-hex-1-ylamino)ethyl] 1,1-bisphosphonic acid
-
 Toxoplasma gondii
1-[(n-hex-1-ylamino)ethyl] 1,1-bisphosphonic acid
-
 Trypanosoma cruzi
1-[(n-oct-1-ylamino)ethyl] 1,1-bisphosphonic acid
-
 Toxoplasma gondii
1-[(n-oct-1-ylamino)ethyl] 1,1-bisphosphonic acid
-
 Trypanosoma cruzi
1-[(n-pent-1-ylamino)ethyl] 1,1-bisphosphonic acid
-
 Toxoplasma gondii
1-[(prop-1-ylamino)ethyl] 1,1-bisphosphonic acid
-
 Toxoplasma gondii
1-[(prop-1-ylamino)ethyl] 1,1-bisphosphonic acid
-
 Trypanosoma cruzi
1-[(prop-2-ylamino)ethyl] 1,1-bisphosphonic acid
-
 Toxoplasma gondii
1-[(prop-2-ylamino)ethyl] 1,1-bisphosphonic acid
-
 Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Toxoplasma gondii
-
-
-
Trypanosoma cruzi
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000013
-
 pH 7.4, 37°C Trypanosoma cruzi 1-[(prop-2-ylamino)ethyl] 1,1-bisphosphonic acid
0.000038
-
 pH 7.4, 37°C Trypanosoma cruzi 1-[(prop-1-ylamino)ethyl] 1,1-bisphosphonic acid
0.000058
-
 pH 7.4, 37°C Trypanosoma cruzi 1-[(n-hept-1-ylamino)ethyl] 1,1-bisphosphonic acid
0.00008
-
 pH 7.4, 37°C Toxoplasma gondii 1-[(n-pent-1-ylamino)ethyl] 1,1-bisphosphonic acid
0.000087
-
 pH 7.4, 37°C Toxoplasma gondii 1-[(n-oct-1-ylamino)ethyl] 1,1-bisphosphonic acid
0.000095
-
 pH 7.4, 37°C Toxoplasma gondii 1-[(n-hept-1-ylamino)ethyl] 1,1-bisphosphonic acid
0.000137
-
 pH 7.4, 37°C Toxoplasma gondii 1-[(n-hex-1-ylamino)ethyl] 1,1-bisphosphonic acid
0.000298
-
 pH 7.4, 37°C Toxoplasma gondii 1-[(prop-1-ylamino)ethyl] 1,1-bisphosphonic acid
0.000337
-
 pH 7.4, 37°C Toxoplasma gondii 1-[(prop-2-ylamino)ethyl] 1,1-bisphosphonic acid
0.00049
-
 pH 7.4, 37°C Trypanosoma cruzi 1-[(n-hex-1-ylamino)ethyl] 1,1-bisphosphonic acid
0.00101
-
 pH 7.4, 37°C Trypanosoma cruzi 1-[(n-oct-1-ylamino)ethyl] 1,1-bisphosphonic acid