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Literature summary for 2.4.99.18 extracted from
- Yeast oligosaccharyltransferase consists of two functionally distinct sub-complexes, specified by either the Ost3p or Ost6p subunit (2005), FEBS Lett., 579, 6564-6568.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Saccharomyces cerevisiae | the enzyme catalyzes the key step of N-glycosylation of proteins in the endoplasmic reticulum by the hetero-oligomeric protein complex oligosaccharyltransferase. It transfers the lipid-linked core-oligosaccharide to selected Asn-X-Ser/Thr sequences of nascent polypeptide chains | ? | - |
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Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
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- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme catalyzes the key step of N-glycosylation of proteins in the endoplasmic reticulum by the hetero-oligomeric protein complex oligosaccharyltransferase. It transfers the lipid-linked core-oligosaccharide to selected Asn-X-Ser/Thr sequences of nascent polypeptide chains | Saccharomyces cerevisiae | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | protein complex oligosaccharyltransferase consists of two isoforms with distinct functions differing only in the presence of the two related Ost3 and Ost6p proteins. The OST6-complex is found to be important for cell wall integrity and temperature stress. Ost3p and Ost6p are not essential for OST activity, and can in part displace each other in the complex when overexpressed | Saccharomyces cerevisiae |
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Release 2023.1 (January 2023)
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