Literature summary for 2.4.99.18 extracted from

Chavan, M.; Rekowicz, M.; Lennarz, W.
Insight into functional aspects of Stt3p, a subunit of the oligosaccharyl transferase. Evidence for interaction of the N-terminal domain of Stt3p with the protein kinase C cascade (2003), J. Biol. Chem., 278, 51441-51447.

Search for more literature for 2.4.99.18

Protein Variants

Protein Variants	Comment	Organism
A162R	no obvious growth defect or staurosporine sensitivity	Saccharomyces cerevisiae
D166A	lethal phenotype	Saccharomyces cerevisiae
D167A	lethal phenotype	Saccharomyces cerevisiae
E168A	lethal phenotype	Saccharomyces cerevisiae
G163R	staurosporine- and temperature-sensitive phenotype	Saccharomyces cerevisiae
G210/V393I	staurosporine- and temperature-sensitive phenotype	Saccharomyces cerevisiae
G210D	staurosporine- and temperature-sensitive phenotype	Saccharomyces cerevisiae
R159A	staurosporine- and temperature-sensitive phenotype	Saccharomyces cerevisiae
R404A	lethal phenotype	Saccharomyces cerevisiae
S158A	no obvious growth defect or staurosporine sensitivity	Saccharomyces cerevisiae
S160A	staurosporine- and temperature-sensitive phenotype	Saccharomyces cerevisiae
S164A	staurosporine- and temperature-sensitive phenotype	Saccharomyces cerevisiae
V161R	no obvious growth defect or staurosporine sensitivity	Saccharomyces cerevisiae
W208A	lethal phenotype	Saccharomyces cerevisiae
Y131A	no growth defect or staurosporine sensitivity	Saccharomyces cerevisiae
Y165A	no obvious growth defect or staurosporine sensitivity	Saccharomyces cerevisiae
Y211A	no growth defect or staurosporine sensitivity	Saccharomyces cerevisiae
Y397A	no growth defect or staurosporine sensitivity	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Saccharomyces cerevisiae	Pkc1p cascade controls N-glycosylation by regulation of Stt3p activity	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	Pkc1p cascade controls N-glycosylation by regulation of Stt3p activity	Saccharomyces cerevisiae	?	-	?

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Release 2023.1 (January 2023)