Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.9 extracted from

  • Andersen, P.S.; Smith, J.M.; Mygind, B.
    Characterization of the upp gene encoding uracil phosphoribosyltransferase of Escherichia coli K12 (1992), Eur. J. Biochem., 204, 51-56.
    View publication on PubMed
Search for more literature for 2.4.2.9

Cloned(Commentary)

Cloned (Comment) Organism
DNA sequence determination and analysis, gene upp belongs to purMN operon, complementation of deficient Escherichia coli strain Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
dUTP
-
 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22500
-
 x * 22500, DNA sequence determination Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
uracil + 5-phospho-alpha-D-ribose 1-diphosphate Escherichia coli pyrimidine salvage enzyme, no de novo synthesis of pyrmidines UMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 K12
-
Escherichia coli
-
 gene upp
-
Escherichia coli
-
 enzyme expression is inducible upon uracil starvation
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activity in different recombinant strain Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
uracil + 5-phospho-alpha-D-ribose 1-diphosphate 5-phospho-alpha-D-ribose 1-diphosphate binding site Escherichia coli UMP + diphosphate
-
 r
uracil + 5-phospho-alpha-D-ribose 1-diphosphate pyrimidine salvage enzyme, no de novo synthesis of pyrmidines Escherichia coli UMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 22500, DNA sequence determination Escherichia coli