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Literature summary for 2.4.2.8 extracted from

  • Hansen, M.R.; Jensen, K.S.; Rasmussen, M.S.; Christoffersen, S.; Kadziola, A.; Jensen, K.F.
    Specificities and pH profiles of adenine and hypoxanthine-guanine-xanthine phosphoribosyltransferases (nucleotide synthases) of the thermoacidophile archaeon Sulfolobus solfataricus (2014), Extremophiles, 18, 179-187.
    View publication on PubMed
Search for more literature for 2.4.2.8

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Saccharolobus solfataricus

Inhibitors

Inhibitors Comment Organism Structure
additional information the activity of HGXPRTase was unaffected by the triphosphates ATP, GTP, CTP or UTP Saccharolobus solfataricus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20600
-
 2 * 20600, SDS-PAGE Saccharolobus solfataricus
45000
-
 gel filtration Saccharolobus solfataricus

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q97W22
-
-
Saccharolobus solfataricus P2 Q97W22
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharolobus solfataricus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Saccharolobus solfataricus GMP + diphosphate
-
 ?
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Saccharolobus solfataricus P2 GMP + diphosphate
-
 ?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Saccharolobus solfataricus IMP + diphosphate
-
 ?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Saccharolobus solfataricus P2 IMP + diphosphate
-
 ?
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Saccharolobus solfataricus XMP + diphosphate
-
 ?
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Saccharolobus solfataricus P2 XMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 20600, SDS-PAGE Saccharolobus solfataricus

Synonyms

Synonyms Comment Organism
6-oxo PRTase
-
 Saccharolobus solfataricus
6-oxopurine PRTase
-
 Saccharolobus solfataricus
gpT-2
-
 Saccharolobus solfataricus
HGXPRTase
-
 Saccharolobus solfataricus
SSO2424
-
 Saccharolobus solfataricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
 maximal activity with hypoxanthine and guanine Saccharolobus solfataricus
7.5
-
 maximal activity with xanthine Saccharolobus solfataricus