Inhibitors | Comment | Organism | Structure |
---|---|---|---|
adenine | no inhibition | Cryptosporidium parvum | |
guanine | competitive | Cryptosporidium parvum | |
hypoxanthine | competitive | Cryptosporidium parvum | |
xanthine | weak, competitive | Cryptosporidium parvum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Cryptosporidium parvum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanine + 5-phospho-alpha-D-ribose 1-diphosphate | Cryptosporidium parvum | - |
GMP + diphosphate | - |
? | |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | Cryptosporidium parvum | - |
IMP + diphosphate | - |
? | |
additional information | Cryptosporidium parvum | no incorporation of xanthine in vivo | ? | - |
? | |
additional information | Cryptosporidium parvum | salvage incorporation of exogenous purine nucleotides, no de novo synthesis | ? | - |
? | |
additional information | Cryptosporidium parvum | enzyme is essential for salvaging exogenous purine bases | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptosporidium parvum | - |
in MDCK cells | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
sporulated oocyst | - |
Cryptosporidium parvum | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.108 | - |
substrate xanthine | Cryptosporidium parvum |
0.28 | - |
substrate hypoxanthine | Cryptosporidium parvum |
0.346 | - |
substrate guanine | Cryptosporidium parvum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
guanine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Cryptosporidium parvum | GMP + diphosphate | - |
? | |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Cryptosporidium parvum | IMP + diphosphate | - |
? | |
additional information | no incorporation of xanthine in vivo | Cryptosporidium parvum | ? | - |
? | |
additional information | salvage incorporation of exogenous purine nucleotides, no de novo synthesis | Cryptosporidium parvum | ? | - |
? | |
additional information | enzyme is essential for salvaging exogenous purine bases | Cryptosporidium parvum | ? | - |
? | |
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Cryptosporidium parvum | XMP + diphosphate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Cryptosporidium parvum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Cryptosporidium parvum |