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Literature summary for 2.4.2.8 extracted from

  • Schmidt, R.; Wiegand, H.; Reichert, U.
    Purification and characterization of the hypoxanthine-guanine phosphoribosyltransferase from Saccharomyces cerevisiae (1979), Eur. J. Biochem., 93, 355-361.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
guanine competitve against hypoxanthine Saccharomyces cerevisiae
hypoxanthine competitive against guanine Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
guanine
-
Saccharomyces cerevisiae
0.023
-
hypoxanthine
-
Saccharomyces cerevisiae
0.05
-
5-phospho-alpha-D-ribose 1-diphosphate
-
Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Saccharomyces cerevisiae
Mg2+ maximal activity at: 1-10 mM Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51000
-
gel filtration Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Saccharomyces cerevisiae

Storage Stability

Storage Stability Organism
-20°C, several months Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
guanine + 5-phospho-alpha-D-ribose 1-diphosphate
-
Saccharomyces cerevisiae GMP + diphosphate
-
?
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
-
Saccharomyces cerevisiae IMP + diphosphate
-
?

Subunits

Subunits Comment Organism
monomer 1 * 51000, SDS-PAGE Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Saccharomyces cerevisiae

pH Range

pH Minimum pH Maximum Comment Organism
5 9.5
-
Saccharomyces cerevisiae

pH Stability

pH Stability pH Stability Maximum Comment Organism
additional information
-
preincubation for 10 min at pH 5.0 or pH 10.5 prior to enzyme assay at pH 8.5 does no affect the enzyme activity Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.018
-
guanine
-
Saccharomyces cerevisiae
0.023
-
hypoxanthine
-
Saccharomyces cerevisiae