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Literature summary for 2.4.2.8 extracted from
- Purification of hypoxanthine-guanine phosphoribosyltransferase of Plasmodium lophurae (1987), Mol. Biochem. Parasitol., 23, 39-45.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 6-Chloropurine | - |
Plasmodium lophurae |  |
| 6-thioinosine | - |
Plasmodium lophurae | |
| 9-beta-Arabinofuranosylhypoxanthine | - |
Plasmodium lophurae | |
| Azaguanine | - |
Plasmodium lophurae | |
| xanthine | - |
Plasmodium lophurae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0024 | - |
guanine | - |
Plasmodium lophurae | |
| 0.0038 | - |
hypoxanthine | - |
Plasmodium lophurae | |
| 0.0062 | - |
6-Mercaptopurine | - |
Plasmodium lophurae | |
| 0.0076 | - |
6-thioguanine | - |
Plasmodium lophurae | |
| 0.36 | - |
8-Azahypoxanthine | - |
Plasmodium lophurae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 79000 | - |
- |
Plasmodium lophurae |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium lophurae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Plasmodium lophurae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Plasmodium lophurae | 6-mercaptopurine ribotide + diphosphate | - |
? | |
| 6-thioguanine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Plasmodium lophurae | 6-thio-GMP + diphosphate | - |
? | |
| 8-azahypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Plasmodium lophurae | 8-aza-IMP + diphosphate | - |
? | |
| guanine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Plasmodium lophurae | GMP + diphosphate | - |
? | |
| hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Plasmodium lophurae | IMP + diphosphate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
pI: 7.6 | Plasmodium lophurae |
| 6 | 10 | substrate hypoxanthine, broad maximum | Plasmodium lophurae |
| 7.5 | 9.5 | substrate guanine, broad maximum | Plasmodium lophurae |
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