General Stability | Organism |
---|---|
inactivation by isoelectric focusing | Leishmania donovani |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-aminopteridine | - |
Leishmania donovani | |
4-aminopyrido(2,3-d)pyrimidine | - |
Leishmania donovani | |
4-aminopyrolo(2,3-d)pyrimidine | - |
Leishmania donovani | |
guanine | weak | Leishmania donovani | |
hypoxanthine | weak | Leishmania donovani | |
xanthine | weak | Leishmania donovani |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics | Leishmania donovani | |
0.007 | - |
adenine | with 5 mM Mg2+ | Leishmania donovani | |
0.036 | - |
4-aminopyrazolo-(3,4-d)pyrimidine | - |
Leishmania donovani | |
0.24 | - |
8-Azaadenine | - |
Leishmania donovani | |
0.89 | - |
2,6-diaminopurine | - |
Leishmania donovani | |
1 | - |
5-aminoimidazole-4-carboxamide | - |
Leishmania donovani | |
1.4 | - |
6-Amino-2-hydroxypurine | - |
Leishmania donovani | |
3.7 | - |
6-Methylpurine | - |
Leishmania donovani |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
25000 | - |
gel filtration | Leishmania donovani |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Leishmania donovani |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
promastigote | - |
Leishmania donovani | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.8 | - |
- |
Leishmania donovani |
Storage Stability | Organism |
---|---|
-70°C, purified enzyme, at least 6 months | Leishmania donovani |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Leishmania donovani | 2,6-diaminopurine ribotide + diphosphate | - |
? | |
4-aminopyrazolo-(3,4-d)-pyrimidine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Leishmania donovani | 4-aminopyrazolo-(3,4-d)-pyrimidine ribotide + diphosphate | - |
? | |
5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Leishmania donovani | 5-amino-4-imidazolecarboxamide ribotide + diphosphate | - |
? | |
6-amino-2-hydroxypurine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Leishmania donovani | 6-amino-2-hydroxypurine ribotide + diphosphate | - |
? | |
6-methylpurine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Leishmania donovani | 6-methylpurine ribotide + diphosphate | - |
? | |
8-azaadenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Leishmania donovani | 8-azaadenosine 5'-phosphate + diphosphate | - |
? | |
adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Leishmania donovani | AMP + diphosphate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Leishmania donovani |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
- |
- |
in absence of Mg2+ and donor substrate, loss of 50% activity after 18 min | Leishmania donovani |
37 | - |
in absence of Mg2+ and donor substrate, loss of 97% activity after 10 min | Leishmania donovani |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Leishmania donovani |
8.4 | 9.1 | - |
Leishmania donovani |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
4-aminopyrido(2,3-d)pyrimidine | - |
Leishmania donovani | |
0.2 | - |
guanine | above | Leishmania donovani | |
0.53 | - |
4-aminopteridine | - |
Leishmania donovani | |
0.8 | - |
hypoxanthine | above | Leishmania donovani | |
0.8 | - |
xanthine | above | Leishmania donovani | |
0.95 | - |
4-aminopyrolo(2,3-d)pyrimidine | - |
Leishmania donovani |