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Literature summary for 2.4.2.45 extracted from
- UbiA (Rv3806c) encoding DPPR synthase involved in cell wall synthesis is associated with ethambutol resistance in Mycobacterium tuberculosis (2015), Tuberculosis, 95, 149-154.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| F176L | the mutation is associated with ethambutol resistance | Mycobacterium tuberculosis |
| K174T | the mutation is associated with ethambutol resistance | Mycobacterium tuberculosis |
| W175C | the mutation is associated with ethambutol resistance | Mycobacterium tuberculosis |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mycobacterium tuberculosis | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate | Mycobacterium tuberculosis | - |
trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate | - |
? |  |
| trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate | Mycobacterium tuberculosis H37Rv | - |
trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | P9WFR5 | - |
- |
| Mycobacterium tuberculosis H37Rv | P9WFR5 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycobacterium tuberculosis | trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate | - |
? | |
| trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycobacterium tuberculosis H37Rv | trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DPPR synthase | - |
Mycobacterium tuberculosis |
| Rv3806c | - |
Mycobacterium tuberculosis |
| ubiA | - |
Mycobacterium tuberculosis |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | overexpression of the wild type enzyme leads to increased resistance to ethambutol in Mycobaterium tuberculosis | Mycobacterium tuberculosis |
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Release 2023.1 (January 2023)
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