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Literature summary for 2.4.2.4 extracted from

  • Javaid, S.; Saad, S.M.; Perveen, S.; Khan, K.M.; Choudhary, M.I.
    2-Arylquinazolin-4(3H)-ones: A novel class of thymidine phosphorylase inhibitors (2015), Bioorg. Chem., 63, 142-151.
    View publication on PubMed
Search for more literature for 2.4.2.4

Inhibitors

Inhibitors Comment Organism Structure
2-(2',5'-dihydroxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
2-(3',4'-dihydroxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
2-(3'-ethoxy-4'-hydroxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
2-(3'-hydroxy-4'-methoxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
2-(3'-hydroxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
2-(4'-hydroxyphenyl)quinazolin-4(3H)-one
-
 Escherichia coli
7-deazaxanthine non-competitive inhibition Escherichia coli
cycloheximide
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
thymidine + phosphate Escherichia coli
-
 thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymidine + phosphate
-
 Escherichia coli thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
dthdpase
-
 Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0002
-
 at pH 7.0 and 30°C Escherichia coli cycloheximide
0.041
-
 at pH 7.0 and 30°C Escherichia coli 7-deazaxanthine
0.0429
-
 at pH 7.0 and 30°C Escherichia coli 2-(3',4'-dihydroxyphenyl)quinazolin-4(3H)-one
0.0595
-
 at pH 7.0 and 30°C Escherichia coli 2-(2',5'-dihydroxyphenyl)quinazolin-4(3H)-one
0.1688
-
 at pH 7.0 and 30°C Escherichia coli 2-(3'-hydroxy-4'-methoxyphenyl)quinazolin-4(3H)-one
0.234
-
 at pH 7.0 and 30°C Escherichia coli 2-(4'-hydroxyphenyl)quinazolin-4(3H)-one
0.256
-
 at pH 7.0 and 30°C Escherichia coli 2-(3'-ethoxy-4'-hydroxyphenyl)quinazolin-4(3H)-one
0.295
-
 at pH 7.0 and 30°C Escherichia coli 2-(3'-hydroxyphenyl)quinazolin-4(3H)-one