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Literature summary for 2.4.2.4 extracted from

  • Soong, R.; Shah, N.; Salto-Tellez, M.; Tai, B.C.; Soo, R.A.; Han, H.C.; Ng, S.S.; Tan, W.L.; Zeps, N.; Joseph, D.; Diasio, R.B.; Iacopetta, B.
    Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy (2008), Ann. Oncol., 19, 915-919.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine low tumour expression level of thymidine phosphorylase is linked with improved outcome for colorectal cancer patients treated with 5-fluorouracil, low thymidine phosphorylase protein expression is predictive of good response to 5-fluorouracil chemotherapy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-deoxy-5-fluorouridine + phosphate
-
Homo sapiens 5-fluorouracil + 5-deoxy-D-ribose 1-phosphate
-
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