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Literature summary for 2.4.2.4 extracted from

  • Liekens, S.; Balzarini, J.; Hernandez, A.I.; De Clercq, E.; Priego, E.M.; Camarasa, M.J.; Perez-Perez, M.J.
    Thymidine phosphorylase is noncompetitively inhibited by 5-O-trityl-inosine (KIN59) and related compounds (2006), Nucleosides Nucleotides Nucleic Acids, 25, 975-980.
    View publication on PubMed
Search for more literature for 2.4.2.4

Inhibitors

Inhibitors Comment Organism Structure
5'-O-trityl-inosine IC50: 0.044 mM, reversible, noncompetitive inhibition with respect to thymidine and phosphate Escherichia coli
5'-O-trityl-inosine IC50: 0.067 mM, reversible, noncmpetitive Homo sapiens

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens P19971
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymidine + phosphate
-
 Escherichia coli thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?
thymidine + phosphate
-
 Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Tpase
-
 Escherichia coli
Tpase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.039
-
 5'-O-trityl-inosine against thymidine Escherichia coli
0.146
-
 5'-O-trityl-inosine against phosphate Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.044
-
 IC50: 0.044 mM, reversible, noncompetitive inhibition with respect to thymidine and phosphate Escherichia coli 5'-O-trityl-inosine
0.067
-
 IC50: 0.067 mM, reversible, noncmpetitive Homo sapiens 5'-O-trityl-inosine